Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia,
- ISBN10 0080585183
- ISBN13 9780080585185
- Publish Date 14 May 2014
- Publish Status Active
- Publish Country US
- Imprint Academic Press
- Format eBook
- Pages 425
- Language English