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Containing articles by internationally renowned scientists, this book covers the use of high performance liquid chromatography (HPLC) techniques for a range of applications. The authors present practical approaches along with clear principles that are easily accessible to the method developer as well as the scientist. They discuss major HPLC analytical modes including size exclusion, ion-exchange, reverse-phase, hydrophobic interactions, immunoaffinity, and more. Highlights of the second edition...

Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for...

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary refe...

This book is written to serve as a principal textbook for introductory pharmacogenomics course, emphasizing pedagogy along with applications in a way useful for students along with professionals needing an accessible resource. The text covers each of the important areas of pharmacogenomics - fundamental principles, relevant technologies, clinical applications, and societal issues. It uses diagrams, flow charts, tables and boxed material in each chapter. The author - who himself teaches and desig...

Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today. Chapters focus specifically on the application of these practices to drugs of abuse. The up-to-date information provided is complemented with thorough references.

Now that prohibitions against stem cell research are relaxing, it is time for the field to move forward with the advances that promise to eliminate so much human suffering. However, it would be naive to ignore the fact that regenerative medicines pose a whole new set of challenges to an industry sector that for decades has geared itself to the development and delivery of traditional pharmaceuticals. Still, significant strides are being made. Unique in its focus, The Delivery of Regenerative Med...

Among the roughly 30,000 species of fish, migratory species account for only 165 species, but most of them are very important fisheries resources. This book presents up-to-date innovative research results on the physiology and ecology of fish migration. It focuses on salmon, eels, lampreys, and bluefin tuna. The book examines migratory behavior, spawning, and behavioral ecology.

Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an integrated view of how the guidelines inform drug development strategic planning and decision-making. - Addresses a consistent need for interpretation, training, and implementation examples of ICH guidelines via case studies - Offers a primary reference point for practitioners addressing the dual challenge of interpretation and practical implem...

An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and methods used to evaluate the nano toxicity and nano safety issues. Written by leading scientists, the book focuses on the bio-interaction of nano materia...

Addressing chemical and biological concepts that are critical in medicinal chemistry, this book illustrates scientific challenges in understanding the molecular basis of diseases and shows technological solutions available to medicinal chemists when tackling diseases. Covers drug design from chemistry fundamentals, history, biology, pharmacy, and case studies Has margin notes encapsulating main point, and boxed material with biographical sketches and stories pertinent to the material Includes bo...