The pathological and behavioral manifestations of alcoholism are caused by a number of biological factors, including genetic predisposition, metabolic alteration and cellular injury. In this issue, investigators explore novel mechanisms underlying alcohol-induced tissue injury, particularly in the liver and in the central nervous system. Special emphasis is placed on understanding ethanol's ability to enhance cellular signaling pathways and protein kinases, which are known to play an important role in mediating cellular damage. Topics discussed include ethanol's effect on cholesterol homeostasis in neural membranes and on cytokine-induced nitric oxide production in astrocytes. Ethanol is shown to enhance oxidative stress and increase the production of reactive oxygen species. Further studies focus on novel pharmacologic agents for preventing relapse and alleviating alcohol-mediated organ damage. Providing an excellent summary of recent progress in biomedical research on alcoholism, this issue is of interest not only to researchers in the alcohol field, but also to investigators in areas related to oxidative stress, tissue injury, signal transduction and neurodegeneration.
- ISBN13 9783805571920
- Publish Date 18 January 2001
- Publish Status Out of Print
- Out of Print 28 April 2023
- Publish Country CH
- Imprint S Karger AG
- Format Paperback
- Pages 150
- Language English