Microbial Communication: Mathematical Modeling, Synthetic Biology and the Role of Noise

by Sarangam Majumdar and Sisir Roy

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Book cover for Microbial Communication

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This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. 

The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, syntheticcooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.


  • ISBN13 9789811574160
  • Publish Date 16 September 2020
  • Publish Status Active
  • Publish Country SG
  • Imprint Springer Verlag, Singapore
  • Edition 1st ed. 2020
  • Format Hardcover
  • Pages 175
  • Language English