This edition is a treatise on the rationale of limiting dilution analysis (LDA). LDA has evolved from its previous role as a basic research laboratory tool in virology and immunology to one pertaining to many different research disciplines and to clinical applications. New methodologies (such as PCR, confocal microscopy, in situ hybridization) have emerged, with the result that single-cell assays can now be performed on a more defined basis, and the quantitation of cells and their precursors is now more accessible to the limiting dilution approach. This book includes both detailed mathematical derivations and methodological descriptions so that the uninitiated scientist can set up and evaluate limiting dilution experiments without further instruction. It also describes particular examples of how LDA is being used to determine clinical practice.
- ISBN10 0198501285
- ISBN13 9780198501282
- Publish Date 1 March 1999
- Publish Status Active
- Out of Print 15 December 2004
- Publish Country GB
- Imprint Oxford University Press
- Edition 2nd Revised edition
- Format Hardcover
- Pages 300
- Language English