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In the spring of 1974, Calliope Stephanides, a student at a girls' school in Grosse Pointe, finds herself drawn to a chain-smoking, strawberry-blond classmate with a gift for acting. The passion that furtively develops between them leads Callie to suspect that she is not like other girls. In fact, Callie has inherited a rare genetic mutation. The biological trace of a guilty secret, this gene has followed her grandparents from the crumbling Ottoman Empire to Detroit and has outlasted the glory d...