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Interest in a specialized microenvironment or “niche” regulating hemopoietic stem cell function has been steadily growing since the idea was first proposed by Ray Schofield over three decades ago. This growing interest, as well as more recently the interest in cellular-molecular-biochemical characterization of not only the hemopoietic stem cell niche but the niches for other stem cells, incited the compilation of Stem Cell Niche: Methods and Protocols. In this volume, scientists have provided pr...

In Neuronal Cell Culture: Methods and Protocols, the latest aspects of the culture of neural cells are explored by experts in the field who also explain the practical and theoretical considerations of the techniques involved.  Starting with a general overview of the neuronal culturing principles that are described, this detailed volume covers cell line models for neural cells, the isolation and propagation of primary cultures, stem cells, transfection and transduction of neural cultures, and oth...

This book presents topical research in the study of leptin, including the interaction of leptin with stress system components; the effects of serum leptin levels of some drugs; leptin as a novel therapeutic reagent in the fight against neurodegenerative diseases; the role of leptin in the activation of the immune system; gender difference in leptin production and leptin senstitivity and neonatal leptin surge.

Entertaining and practical, this new edition of Basic Pathology is a straightforward introduction to pathology and the mechanisms of disease. It puts pathology into its historical, scientific and clinical context for all medical, dental and nursing students and other health professionals. Basic Pathology has been brought fully up-to-date in this new edition, and once again covers four main themes: What is a Disease, Defence Against Disease, Circulatory Disorders, and Disorders of Cell Growth;...

This new volume of Methods in Cell Biology looks at lipid droplets LDs, covering sections on analyses of LDs in model systems, cell/tissue-specific analyses of LDs and imaging and in vitro analyses of LD biogenesis and growth. Chapters are written by experts in the field. With cutting-edge material, this comprehensive collection is intended to guide researchers of LDs for years to come.

When inserted into cells, or used extracellularly in special ways, micropipettes can provide channels for recording the electrical activity of single cells, even cells buried in a mass of tissue such as the brain. Micropipettes can also provide channels for injecting substances into individual cells for a variety of experimental purposes, and this is likewise a necessary step in genetic engineering. Micropipettes are thus critical tools in modern cell physiology, but many aspects of how they are...

Looking at Ribozymes: From Atomic to Molecular and Cellular Scales introduces ideas on how ribozymes "work" through a comparison of their common features and specificities. It covers how the (macro) molecular organization at different scales make it possible, what function they carry, where they are found, how they evolved, and how have they been used. The book emphasizes common and specific features of natural and artificial ribozymes, from the basics, to more advanced aspects, making it ideal...