This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have bee...
Nonstandard Finite Difference Schemes: Methodology And Applications
by Ronald E Mickens
This second edition of Nonstandard Finite Difference Models of Differential Equations provides an update on the progress made in both the theory and application of the NSFD methodology during the past two and a half decades. In addition to discussing details related to the determination of the denominator functions and the nonlocal discrete representations of functions of dependent variables, we include many examples illustrating just how this should be done.Of real value to the reader is the i...
An Introduction to Dynamics of Colloids (Studies in Interface Science)
by Jan K G Dhont and J K G Dhont
One of the few textbooks in the field, this volume deals with several aspects of the dynamics of colloids. A self-contained treatise, it fills the gap between research literature and existing books for graduate students and researchers. For readers with a background in chemistry, the first chapter contains a section on frequently used mathematical techniques, as well as statistical mechanics.Some of the topics covered include:* diffusion of free particles on the basis of the Langevin equation*th...
[Chemoinformatics of Natural Products, Volume 1+2] (De Gruyter STEM)
Vol. 1 of Chemoinformatics of Natural Products presents an overview of natural products chemistry, discussing the chemical space of naturally occurring compounds, followed by an overview of computational methods.
Computational Nanotoxicology
The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed for regular chemicals cannot always be applied explicitly in nanotoxicology. This book discusses the current state o...
Hydrogen-bonding Research In Photochemistry, Photobiology, And Optoelectronic Materials
As one of the typical intermolecular interactions, hydrogen-bonding plays a significant role in molecular structure and function. When the hydrogen bond research system is connected with the photon, the hydrogen-bonding effect turns to an excited-state one influencing photochemistry, photobiology, and photophysics. Thus, the hydrogen bond in an excited state is a key topic for understanding the excited-state properties, especially for optoelectronic or luminescent materials.The approaches presen...
The concept of a chemical bond evolved from a variety of experimental observations. It became useful to understand, at times even predict, the molecular structure, reactivity and mechanism of chemical reactions. Every aspect of the concept of bonding received a quantitative interpretation from the advent of quantum mechanics and its application to chemistry.In Lectures on Chemical Bonding and Quantum Chemistry the reader will find a comprehensive discourse on the basic interpretation of the chem...
Stochastic Lagrangian Modeling for Large Eddy Simulation of Dispersed Turbulent Two-Phase Flows
by Abdallah Sofiane Berrouk
Isometric Graph Paper Notebook (Graph Paper - Cat, #6)
by Isometric Hexagon Graph & Grid Paper Exp
Vol. 1 of Chemoinformatics of Natural Products presents an overview of natural products chemistry, discussing the chemical space of naturally occurring compounds, followed by an overview of computational methods.
Elementary Methods of Molecular Quantum Mechanics
by Valerio Magnasco
Elementary Methods of Molecular Quantum Mechanics shows the methods of molecular quantum mechanics for graduate University students of Chemistry and Physics. This readable book teaches in detail the mathematical methods needed to do working applications in molecular quantum mechanics, as a preliminary step before using commercial programmes doing quantum chemistry calculations. This book aims to bridge the gap between the classic Coulson's Valence, where application of wave mechanical principle...
This course is about 50 per cent laboratory-based, and features decision-making activities which give students practice in applying their chemistry knowledge in realistic decision-making situations. Concepts are presented on a "need-to-know" basis, allowing students to experience the use and application of their chemistry learning. Because of the nature of the issues covered in the specific units, students learn more organic and biochemistry than in traditional courses, as well as some environme...
In studying biology, one of the more difficult factors to predict is how parents' attributes will affect their children and how those children will affect their own children. Organizing and calculating those vast statistics can become extremely tedious without the proper mathematical and reproductive knowledge. Attractors and Higher Dimensions in Population and Molecular Biology: Emerging Research and Opportunities is a collection of innovative research on the methods and applications of populat...