Computational Chemistry F.E.C.S. Conference (AIP Conference Proceedings, v.330)
This text details the proceedings of the ECCC 1 Computational Chemistry FECS Conference.
The TACC conference deals with the theoretical methods and application of computational chemistry. The theoretical aspects include development of computational and statistical techniques, quantum and statistical mechanical methods that could be used to solve complicated scientific problems, which will be applied to various fields of chemistry, physics and biology. Since the first applications of computer in chemistry in the early 1960s, 'computational chemistry' has evolved today to be at the va...
Prudent Practices for Handling Hazardous Chemicals in Laboratories
by Herbert O. House
A Practical Guide to Metabolomics Applications in Health and Disease (Learning Materials in Biosciences)
This well-accessible textbook constitutes a practical guide to metabolomics approaches and applications in an integrative manner. Illustrated by numerous real-life examples and case studies the book teaches how to set up and carry out metabolomics experiments, from sample collection to storage techniques, and guides the reader through the potentials and challenges of metabolite analysis. In addition, this textbook shows how to obtain insights into molecular mechanisms deployed in different phy...
This collection of challenging experiments will help get readers up to speed on laboratory techniques, safety and experimental procedures. Each experiment is presented with concise objectives, a comprehensive list of techniques, and detailed lab intros and step by step procedures. Beran also integrates numerous Dry Labs, experiments that do not involve chemicals but reinforce the reader's knowledge of general chemistry topics such as nomenclature, oxidation numbers, and atomic and molecular stru...
The laboratory course described in this lab manual emphasizes experimental design, data analysis, and problem solving. Inherent in the design is the emphasis on communication skills, both written and oral. Students work in groups on open-ended projects in which they are given an initial scenario and then asked to investigate a problem. There are no formalized instructions and students must plan and carry out their own investigations.
Chemical Demonstrations: Volume 2 (Chemical Demonstrations)
Follows the philosophy and format of the first volume. Contains 112 demonstrations appropriate for any introductory chemical program. Offers clear, concise text that details each demonstration. Explains how to do it, what the reactions are, and how to prepare materials and solutions. Provides a cross listing of demonstrations and chemical topics, thus allowing you to quickly find the right demonstration to fit a specific topic. Will benefit both student and teacher.
Phytochemistry of Plants of Genus Rauvolfia (Phytochemical Investigations of Medicinal Plants)
by Brijesh Kumar, Sunil Kumar, Vikas Bajpai, and KP Madhusudanan
Rauvolfia species, commonly known as Sarpagandha, has been traditionally used in Ayurveda for curing high blood pressure, hypertension, snake bites, fever, and mental illnesses. Due to its wide variety and differences in chemical composition, it is necessary to develop an efficient and reliable method for rapid screening and determination of phytochemicals in the extracts of the Rauvolfia species. This book will provide qualitative and quantitative comparative phytochemical investigations of sel...
Handbook of Infrared and Raman Spectra of Inorganic Compounds and Organic Salts
by M. Anne Leugers
Heterocyclic Antitumor Antibiotics (Topics in Heterocyclic Chemistry, #2)
The series "Topics in Heterocyclic Chemistry" will present critical reviews on "Heterocyclic Compounds" within topic related volumes dealing with all aspects such as synthesis, reaction mechanisms, structure complexity, properties, reactivity, stability, fundamental and theoretical studies, biology, biomedical studies, pharmacological aspects, applications in material sciences etc. Metabolism will be also included which will provide information useful in designing pharmacologically active agents...
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed in...
Copper-Catalyzed Electrophilic Amination of sp2 and sp3 C−H Bonds (Springer Theses)
by Stacey L. McDonald
This thesis reports the latest developments in the direct amination of various C−H bonds using an H−Zn exchange/electrophilic amination strategy. McDonald and co-workers reveal this approach to be a rapid and powerful method for accessing a variety of functionalized amines. The material outlined in this book shows how McDonald achieved C−H zincation using strong, non-nucleophilic zinc bases and subsequent electrophilic amination of the corresponding zinc carbanions with copper as a catalyst a...
Zaozao Qiu shows in this thesis that transition metals can mediate or catalyze the cycloaddition or coupling reactions of carboryne with alkynes or alkenes to afford benzocarboranes, alkenylcarboranes or dihydrobenzocarboranes. These results represent powerful strategies to assemble useful complex molecules from very simple precursors in a single operation. Carboranes have many applications in medicine. However, their unique structures make derivatization difficult and the limited efficient synt...
Essential Oil Research
This book highlights the advances in essential oil research, from the plant physiology perspective to large-scale production, including bioanalytical methods and industrial applications. The book is divided into 4 sections. The first one is focused on essential oil composition and why plants produce these compounds that have been used by humans since ancient times. Part 2 presents an update on the use of essential oils in various areas, including food and pharma industries as well as agriculture...
Laser Control and Manipulation of Molecules (ACS Symposium Series No.821)
Laser Control and Manipulation of Molecules provides advances in the studies of chemical dynamics and photochemistry using emerging laser technologies. The book examines both theoretical and experimental advances in this field, and includes such topics as efficient selectivity in chemical reactions, new pulse shaping techniques, and new tools for realistic control and manipulation of molecules. The book is divided into three sections that cover coherent - optimal control, intense fields, and ali...
Total Synthesis of Plakortide E and Biomimetic Synthesis of Plakortone B (Springer Theses)
by Xiao-Yu Sun
In his thesis, Xiaoyu Sun conducts the first total synthesis of all possible stereoisomers of plakortide E and also confirms the absolute configuration of natural plakortide E. Xiaoyu Sun subsequently converts Plakortide E methyl ester to plakortone B in a biomimetic conversion. Construction and functionalization of cyclic peroxides are notoriously difficult due to the very low O-O bond dissociation energy. Plaktoride E is isolated from the Jamaican marine sponge platorits halichondrioides and c...
Pharmacognostical Evaluation of Endomycophytes from Western Ghats Pteridophytes
by Aneesh Nair
Photodynamic Therapy with ALA (Comprehensive Series in Photochemical & Photobiological Sciences, Volume 7)
Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of diseases. One common strategy used during this light activated process is to induce the accumulation of significant amounts of a photosensitising agent in the diseased tissue. The naturally occurring amino acid 5-aminovulinic acid (ALA) is used to produce high levels of the photosensitizer, Protoprophyin IX, in the therapy known as ALA-PDT. Written by experts in the field Photodynamic the...
Detection of Drug Misuse
Drug misuse and dependence is an ever evolving field of study, which has exploded over recent years owing to the advent of the internet. Due to the ever-growing number of young people using drugs recreationally and the privatisation of drug screening and detection services, there is the need to disseminate evidence-based information concerning the technology and methods available for studying this expanding field. Detection of Drug Misuse describes the current state-of-the-art techniques used fo...
Protein–Protein Interaction Regulators (Drug Discovery, Volume 78)
New genomic information has revealed the crucial role that protein–protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the fiel...
Organoselenium Compounds in Biology and Medicine
Organoselenium shows incredible promise in medicine, particularly cancer therapy. This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications. Divided into three sections, the first section describes synthetic advances in bioactive selenium compounds, revealing how organoselenium compound toxicity, redox properties and specificity can be further tuned. The second sec...
Tutorials in Chemoinformatics
30 tutorials and more than 100 exercises in chemoinformatics, supported by online software and data sets Chemoinformatics is widely used in both academic and industrial chemical and biochemical research worldwide. Yet, until this unique guide, there were no books offering practical exercises in chemoinformatics methods. Tutorials in Chemoinformatics contains more than 100 exercises in 30 tutorials exploring key topics and methods in the field. It takes an applied approach to the subject with a s...