DNA Binders and Related Subjects (Topics in Current Chemistry, #253)
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are...
This book reviews the fundamental aspects of quinoxaline chemistry: synthesis, reactions, mechanisms, structure, properties, and uses. The first four chapters present a survey of the developments in quinoxaline chemistry since the publication of the monograph on “Condensed Pyrazines” by Cheeseman and Cookson in 1979. These chapters give comprehensive coverage of all the methods of the synthesis of quinoxalines and the important quinoxaline-containing ring systems such as thiazolo[3,4-a]-, pyrro...
Atypical Elements in Drug Design (Topics in Medicinal Chemistry, #17)
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and...
Steroid Analysis
The second edition of this book has drawn heavily on the first edition but a huge amount of research on steroid analysis has been published over the last 15 years. As a result, the Editors decided to let the first edition of this book stand on its own and direct readers interested in pre-1995 steroid analysis to it, simply because the post-1995 research can on its own fill the second edition. We have tried to keep a balance but equally have allowed authors of each chapter a significant degree of...
Recent Advances in QSAR Studies (Challenges and Advances in Computational Chemistry and Physics, #8)
Since the inception of this volume, the world's nancial climate has radically changed. Theemphasishasshiftedfromboomingeconomiesandeconomicgrowth totherealityofrecessionanddiminishingoutlook. Witheconomicdownturncomes opportunity,inallareasofchemistryfromresearchanddevelopmentthroughto productregistrationandriskassessment,replacementsarebeingsoughtforcostly time-consumingprocesses. Leadingamongstthereplacementsaremodelswithtrue predictivecapability. Ofthesecomputationalmodelsarepreferred. This v...
Contents: L. Banfi ∙ A. Basso ∙ R. Riva: Synthesis of Heterocycles Through Classical Ugi and Passerini Reactions Followed by Secondary Transformations Involving One or Two Additional Functional Groups.- V.A. Chebanov ∙ K. A. Gura ∙ S.M. Desenko: Aminoazoles as Key Reagents in Multicomponent Heterocyclizations.- Y. Huang ∙ K. Khoury ∙ A. Dömling: Piperazine Scaffolds by Multicomponent 3 Reactions: The Piperazine Space 4 in MCR Chemistry 5 Deep MCR Piperazine Space.- N. Elders ∙ E. Ruijter ∙ V.G....
Ruthenium-NHC-katalysierte asymmetrische Arenhydrierung (Bestmasters)
by Christoph Schlepphorst
Christoph Schlepphorst entwickelt ein rationales Ligandendesign für die Ruthenium-NHC-katalysierte asymmetrische Hydrierung (hetero-)aromatischer Verbindungen. Zudem synthetisiert er eine Reihe von entsprechenden Carbenvorläufern und charakterisiert diese. Die synthetisierten Carbenvorläufer werden außerdem auf ihre Eignung als Liganden in Ru-NHC-katalysierten Hydrierreaktionen getestet. Der Autor optimiert bei diesem Vorgehen die asymmetrische Hydrierung ungeschützter monosubstituierter Pyrazin...
This 8-volume set provides a systematic description on 8,350 active marine natural products from 3,025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed as well. The 3rd volume mainly illustrates the molecular formula and structures of alkaloids. .
Nucleotide Analogues as Antiviral Agents (ACS Symposium, #401)
Largely in response to the AIDS epidemic, the amount of research directed toward the discovery of antiviral agents has greatly expanded. This new volume focuses on the potential of nucleotides to exert potent in vivo antiviral effects. It presents the findings of an international group of scientists who are carrying out research at the forefront of the nucleotide drug design. Twelve chapters describe many new concepts and results, much of which has been previously unpublished. This book assemble...
Microfabricated Sensors (ACS Symposium, #815)
by Richard Kordal, Arthur Usmani, and Wai Tak Law
This volume describes the important application of the Bio- or DNA-Chips in biomedical research, such as gene expression studies and methods of construction. Microfabricated Sensors: Application of Optical Technology for DNA Analysis describes novel optical sensing and processing technologies that are being employed by researchers in this field. Specific topics include DNA Chips, detection technologies and optical sensing and processing.
Karrierechancen in der Biotechnologie und Pharmaindustrie
by Toby Freedman
Meols
Meols, on the north coast of the Wirral Peninsula (north-west England), is one of Britain's richest and most fascinating archaeological landscapes. As a low sandy promontory known as Dove Point was gradually destroyed by the sea during the 19th century, the remains of ancient settlement sites were exposed along the foreshore and in the sand-dunes near the water's edge. Thousands of artefacts from the prehistoric, Roman, medieval and post-medieval periods were picked up from the eroding coastline...
Advances in Quantum Chemistry (Advances in Quantum Chemistry)
Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on the theory of heavy ion physics in medicine.
Biopharmaceutical Manufacturing (de Gruyter Stem)
by Gary Gilleskie
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyro...
Safe Storage of Laboratory Chemicals
Safe Storage of Laboratory Chemicals, Second Edition is a comprehensive guide which allows readers to assess and improve the safety of their laboratory operations when storing chemicals. By applying the information in this book, readers can create a safer place to work through a safer storage environment, wiser storage practices and procedures, informed personnel, and the intelligent use of information. There has seen a surge in the demand for chemical safety and information relating to a safe w...
Improving Safety in the Chemical Laboratory
The work of accident prevention in the lab begins with foresight.Discerning "close calls"--near accidents--early enough preventsthem from turning into full-fledged mishaps, mishaps that cost timeand money, and which could result in injury. Improving Safety inthe Chemical Laboratory is an accident prevention handbook for theprofessional in the lab that shows how to detect and eliminate thecauses of dangerous mishaps--and virtually "hazard proof" any labenvironment. In unequivocally clear and prac...
Flow-Chemie für die Synthese von Heterocyclen
Dieser Band gibt einen Überblick über die jüngsten Entwicklungen und die Möglichkeiten des Einsatzes der Fließchemie im Bereich der heterozyklischen Synthese. Der heterozyklische Ring ist das wichtigste strukturelle Motiv in der überwiegenden Mehrheit der Naturstoffe und pharmazeutischen Verbindungen, da er abstimmbare Wechselwirkungen mit dem biologischen Ziel ermöglicht und zudem ein gewisses Maß an struktureller und metabolischer Stabilität verleiht. In jüngster Zeit hat die Fließchemie einen...
Write Like a Chemist: A Guide and Resource focuses on four types of writing that are common in chemistry: the journal article, conference abstract, scientific poster, and research proposal. Users of the book will learn to write through a host of exercises, ranging in difficulty from correcting single words and sentences to writing professional-quality papers, abstracts, posters, and proposals. This second edition of Write Like a Chemist has been updated to include new excerpts from the primar...
A Computational Approach to Chemistry (Physical Chemistry Texts)
by David Michael Hirst
The main aim of this text is to demonstrate how computational methods are used to model chemical systems and to generate data which are complementary to experimental data. The computational techniques used in treating each problem are outlined with minimum detail of the numerical analysis involved. Each topic is illustrated with examples.
Advances in QSAR Modeling (Challenges and Advances in Computational Chemistry and Physics, #24)
The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included -...
Counselling Skills for Social Workers (Student Social Work)
by Hilda Loughran
Counselling skills are very powerful. Really listening and providing compassionate empathy without judging is a core part of social work practice with service users. This book provides a theoretically informed understanding of the core skills required to provide counselling interventions that work. It provides detailed discussion of three core skills which are identified as: talking and responding, listening and observing and thinking. Over 11 chapters these core skills are described in terms...
An important resource for the synthesis of intermediates of specialty chemicals, pharmaceuticals and fine chemicals. Aromatic Hydroxyketones from Butanone to Dotriacontanone provides the reader with exhaustive information covering structure, preparation, physicochemical characteristics, as well as a related bibliography. The handbook is presented in dictionary style, with a logical classification of the ketones, making the information easily available for consultation. The book is aimed at those...