Creative Chemical Sensor Systems (Topics in Current Chemistry, #277)
Since several excellent books have appeared on the issue of chemical and biochemical sensing, this compendium concentrates on recent creative new approaches using chemical means for the detection and quanti?cation of - portant analytes. These are presented either from a technical viewpoint or fromtheperspectiveofselectivemolecularrecognitionwitharti?cialreceptor molecules. Consequently, the entire book is subdivided into two categories, i. e. , natural targetsand detection techniques. In the ?rs...
Regulated Systems for Multiphase Catalysis (Topics in Organometallic Chemistry, #23)
Multiphase catalysis in recent years has been shown in academia and industry to be the emerging key technology for the competitive and sustainable production of fine chemicals in the next decades. It convincingly unites the indispensable core advantages of homogeneous catalysis with future governmental and industrial sustainability criteria. In a joint effort by seven of Germany's most distinguished scientists in the field and four renowned industry partners a research consortium was established...
Novel Optical Resolution Technologies (Topics in Current Chemistry, #269)
After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capableofresolvingthesurface as wellas theinsidestructureofcrystalsattheatomiclevelwhilenewhigh-performance computingresourcesaffordthecapabilityofmodelingthecomplexlarge-scale alignmentsnecessarytosimulatecrystallizationinrealsystems.Asaresult,the science of crystallization has shifted gradually fromstatic to dynam...
High Performance Liquid Chromatography
by Moustafa A. Khalifa and Omar Al Sayed Omar
The book provides an indispensable guide on how to use HPLC in pharmaceutical analysis and drug control. Following a hands-on approach, the authors give practical advices how to prepare stationary and mobile phases, choose a suitable detector and set up an HPLC analysis. The publication gives insight into the key pharmaceutical applications of HPLC and the latest requirements of the major regulatory agencies.
This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologicall...
Proteinkinase Inhibitors (Topics in Medicinal Chemistry, #36)
This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field. Chapters written by experts from industry and academia cover the function, structure and topology of Proteinkinases, molecular modelling, disclose how to achieve high level of selectivity for kinase inhibitors, and exploit kinase inhibitors for cancer treatment. Particular...
Laubengayer Experiments & Probablty Chem 2
by Albert Washington Laubengayer
This book provides targeted support for students taking courses at the undergraduate level involving electrochemical methods and voltammetry, precision analytical techniques used in chemical engineering, chemical research and development, and pharmaceutical science. The learning method applied in this book, and the contents chosen, have been specifically tried-and-tested to support students preparing for exams, and for those having difficulty absorbing concepts and attaining an analytical unders...
Enzyme (Handbuch Der Physiologisch- Und Pathologisch-Chemischen Anal, TEIL B)
by Friedrich H Bruns, Felix Hoppe-Seyler, Konrad Lang, Gunther Siebert, and Hans Thierfelder
Stereochemistry - Fundamental Terms approaches students, lecturers and scientists in chemistry, biochemistry, pharmacy, medicine and biology dealing with the phenomenon of chirality. The description of three-dimensional structures and the resulting consequences on reactions or component-receptor-interaction requires a detailed presentation of chemical structures as well as a clear and precise terminology. This is even more important in view of the increasing interdisciplinary exchange of scienti...
Neue Reaktivitäten in RhIII-Katalyse für die effiziente Synthese hochwertiger Reaktionsprodukte (Bestmasters)
by Andreas Lerchen
Andreas Lerchen untersucht verschiedene Parameter von unterschiedlichen dirigierenden Gruppen für neuartige Transformationen mittels RhodiumIII-Katalyse. Die dabei gefundenen Methoden werden zunächst erfolgreich optimiert und anschließend auf den Anwendungsbereich getestet. Dadurch kann der Autor ein neuartiges breites Reaktionsspektrum für RhIII-katalysierte C–H-Bindungsaktivierung abdecken. Unter den erhaltenen Produkten befinden sich auch die pharmazeutisch bedeutsamen neutralen Cinnolin-Deri...
Cooperativity and Regulation in Biochemical Processes
by Arieh Y Ben-Naim
This book evolved from a graduate course on applications of statistical thermody- namics to biochemical systems. Most of the published papers and books on this subject used in the course were written by experimentalists who adopted the phenomenological approach to describe and interpret their results. Two outstanding papers that impressed me deeply were the c1assical papers by Monod, Changeux, and Jacob (1963) and Monod, Wyman, and Changeux (1965), where the allosteric model for regulatory enzym...
Synthesis of Saturated Oxygenated Heterocycles II (Topics in Heterocyclic Chemistry, #36)
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Personalized Medicine with a Nanochemistry Twist (Topics in Medicinal Chemistry, #20)
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and...
Computational Modelling of the Human Islet Amyloid Polypeptide (Springer Theses)
by Katrine Kirkeby Skeby
This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them. Katrine Skeby critically assesses and compares both the literature and the experiments performed by other researchers, which further elevates the quality and relevance of her own work. Amyloid proteins are highly complex, and this research provides unparalleled insights, especially with regard to the origin of cytotoxicity and to developing technologies for early detection, r...
Cycloadditions in Bioorthogonal Chemistry (Topics in Current Chemistry Collections)
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest t...
Polymer Libraries (Advances in Polymer Science, #225)
This is truly an exciting time to be in the ?eld of polymer science. Advances in polymerization methods are providing polymer scientists with the ability to specify and control polymer composition, structure, architecture, and molecular weight to a degree that was not possible just a decade ago. This, in turn, is resulting in many novel application possibilities of polymers ranging from drug delivery systems and nanolithographyto stimuli-responsivematerials and many others. In addition,many of t...
Inclusion Polymers (Advances in Polymer Science, #222)
Since Hermann Staudinger coined the concept of macromolecules as covalently linked very large molecular entities in 1922, the main focus of ongoing research has been on the synthesis of polymers and copolymers leading to a great variety of stable, structural, and functional materials. On the other hand, during the last 15 years the knowledge about supramolecular self-organization of polymers with low molecular-weight compounds by reversible non-covalent interactions gained increasing attention....
Anti-Angiogenesis Drug Discovery and Development Volume 4
by Iqbal Choudhary and Atta-ur Rahman
Advances in Clinical Chemistry (Advances in Clinical Chemistry)
Volume 48 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics ranging from basic biochemical exploration to cutting-edge microarray technology.