Are new reproductive and genetic technologies racing ahead of a society that is unable to establish limits to their use? Have the "new genetics" outpaced our ability to control their future applications? This book examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called "designer baby" method. Using detailed empirical evidence, the authors show that far from being a runaway technology, the regulatio...
Methods of Microarray Data Analysis V (Lecture Notes in Physics, #339)
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA (Critical Assessment of Microarray Data Analysis) conference was the first to establish a forum for a cross section of researchers to look at a common data set and apply innovative analytical techniques to microarray data. Methods of Microarray Analysis V includes selected papers from CAMDA'04, and focuses on data sets relating to a significant global health issue,...
Non Coding RNAs in Plants (RNA Technologies)
In the most recent years, each of the RNA silencing pathways of plants have appeared to generate ncRNAs with dedicated functions, specialized biological activities and specific functional scopes. RNA silencing plays a crucial role in coordinating the expression, stability, protection and inheritance of eukaryotic genomes. It compromises several mechanisms, that invariably depend on core small non coding RNAs and that achieve dedicated sequence-specific functions. RNA silencing has been recognize...
Genome Plasticity in Health and Disease (Translational and Applied Genomics)
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-nu...
Clinical DNA Variant Interpretation (Translational and Applied Genomics)
Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practic...
Prenatal Genetic Counseling
**Selected for Doody’s Core Titles® 2024 in Clinical Genetics** Prenatal Genetic Counseling: Practical Support for Prenatal Diagnostics, Decision-Making, and Dealing with Uncertainty provides a foundation for new research and a one-stop source for physicians, genetic counselors, psychologists, social workers, general practitioners, grief workers, translational researchers, and administrators seeking to work in the field of clinical genomics ethically and in full consideration of patients’ psych...
Cell Fusion (Methods in Molecular Biology, #475)
Exciting work in the past decade has revealed commonalities and differences among individual cell fusion events. In Cell Fusion: Overviews and Methods, a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion and methods that present classic and state-of-the-art experimental approaches in a variety of systems. Divided into two convenient parts, the volume begins with nine overviews which describe different cell fusion events in models fro...
Evolution Of Life Histories
There are many different types of organisms in the world: they differ in size, physiology, appearance, and life history. The challenge for evolutionary biology is to explain how such diversity arises. The Evolution of Life Histories does this by showing that natural selection is the principal underlying force molding life history variation. The book describes in particular the ways in which variation can be analyzed and predicted. It covers both the genetic and optimization appro...
Combining medical knowledge with sympathetic common sense, this completely updated comprehensive handbook offers help and advice to all parents and carers of children with Down's syndrome, and shows them how to help their children flourish and reach their full potential. Written in association with the Down's Syndrome Association, this book goes beyond the average introduction to Down's syndrome and addresses the questions, practical or otherwise, that parents will often find themselves asking,...
Retroviral Reverse Transcriptases (Molecular Biology Intelligence Unit)
by Simon Litvak
Computing for Comparative Microbial Genomics (Computational Biology, #8)
by David W Ussery, Trudy M. Wassenaar, and Stefano Borini
Overview and Goals This book describes how to visualize and compare bacterial genomes. Sequencing technologies are becoming so inexpensive that soon going for a cup of coffee will be more expensive than sequencing a bacterial genome. Thus, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes. It is a long road from molecular biology to systems biology, and in a sense this text can be thought of as a path bridging...
Mastering Genetics without Pearson eText -- Instant Access -- for Essentials of Genetic Analysis
by Mark F. Sanders and John L. Bowman
Principles of Gene Manipulation 6e
by Sandy B. Primrose, Dr Richard Twyman, and Bob Old
In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysi...
The Cloning Sourcebook
A distinguished collection of papers by leading scientists and bioethicists on the science and social issues related to large-animal cloning. The book details the prospective medical benefits for development of pharmaceuticals in transgenic animals and of organs for xenotransplants, and the implications for the possibility of human cloning. It provides a thorough, authoritative assessment and explanation of what has been done, including recent animal cloning, and what the possibilities are for t...
Microarray Data Analysis (Methods in Molecular Biology, #377)
by Michael J Korenberg
This volume is an up-to-date guide on microarray data analysis. "Microarray Data Analysis" provides information on an array of topics including genomic signal processing, predictive models of gene regulation, analysis of comparative genomic hybridization data on cDNA microarrays, and interpreting microarray results with gene ontology and MeSH ontology.
This new textbook for students taking courses in evolution is addressed to one of the most difficult questions evolutionary biology, that of selection. Covering both artificial and natural selection, the author has written a short, readable text that will appeal to students and professionals alike. how the nature of the process determines the nature of evolutionary change.