A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Steven Lipkin and Jon Luoma posit that today’s genomics is like...
Epigenetics and Metabolomics (Translational Epigenetics)
Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as...
Plant Molecular Evolution
Plant molecular biology has produced an ever-increasing flood of data about genes and genomes. Evolutionary biology and systematics provides the context for synthesizing this information. This book brings together contributions from evolutionary biologists, systematists, developmental geneticists, biochemists, and others working on diverse aspects of plant biology whose work touches to varying degrees on plant molecular evolution. The book is organized in three parts, the first of which i...
Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in...
Evolutionary Theory and Processes: Modern Horizons
Evolution is the most profound of human ideas integrating all natural phenomena: cosmic, biological, and cultural into a continuous universal change. This volume deals with evolutionary observations, experiments, and theories contributing to a deeper understanding of the evolutionary process, th honoring the 75 birthday of Eviatar (Eibi) Nevo. I first met Eibi in 1966 when he was a Fellow in the Museum of Comparative Zoology at Harvard University and working mostly on cricket frog vocalization a...
Designing Our Descendants
The Statistics of Gene Mapping (Statistics for Biology and Health)
by David Siegmund and Benjamin Yakir
This book details the statistical concepts used in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. It presents elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. Each chapter contains exercises, both theoretical and computational, some routine and others that are more cha...
This book adopts an experimental approach to understanding the mechanisms of evolution and the nature of evolutionary processes, with examples drawn from microbial, plant and animal systems. It incorporates insights from remarkable recent advances in theoretical modelling, and the fields of molecular genetics and environmental genomics. Adaptation is caused by selection continually winnowing the genetic variation created by mutation. In the last decade, our knowledge of how selection operates o...
Manipulating the Mouse Embryo
by Andras Nagy, Marina Gertsenstein, Kristina Vintersten, and Richard R. Behringer
Methods of Microarray Data Analysis V (Lecture Notes in Physics, #339)
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA (Critical Assessment of Microarray Data Analysis) conference was the first to establish a forum for a cross section of researchers to look at a common data set and apply innovative analytical techniques to microarray data. Methods of Microarray Analysis V includes selected papers from CAMDA'04, and focuses on data sets relating to a significant global health issue,...
Chromatin Signaling and Neurological Disorders (Translational Epigenetics)
Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-ba...
Secondary Findings in Genomic Research (Translational and Applied Genomics)
Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and la...
Evolution Of Life Histories
There are many different types of organisms in the world: they differ in size, physiology, appearance, and life history. The challenge for evolutionary biology is to explain how such diversity arises. The Evolution of Life Histories does this by showing that natural selection is the principal underlying force molding life history variation. The book describes in particular the ways in which variation can be analyzed and predicted. It covers both the genetic and optimization appro...
Ancient DNA Typing is a comprehensive manual about the analysis of ancient and degraded DNA. It is an equally useful textbook and working tool for various disciplines such as: Anthropology, Archaeology, Forensic Medicine, Conservation Biology, Environmental Sciences and Food Engineering. The reader benefits from a clear division of strategies, methods and applications with many interesting examples of the analysis of historic skeletal and cultural remains. The book contains a detailed protocol c...
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese...
Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavio...
Clinical DNA Variant Interpretation (Translational and Applied Genomics)
Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practic...
Bioluminescence And Chemiluminescence - Proceedings Of The 11th International Symposium
Light-emitting reactions occur in some living organisms, and are also now extensively exploited by industry and various branches of biomedical science. Luminescence from the natural world, particularly from marine organisms, is increasingly being harnessed by genetic and chemical manipulation to enhance the quality of human life. This volume contains cutting-edge contributions from most of the world's leading researchers in this field. It presents an up-to-date compilation of the range of biomed...