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Kaplan Medical's USMLE Step 1 Lecture Notes 2021: 7-Book Set offers in-depth review with a focus on high-yield topics in every discipline-a comprehensive approach that will help you deepen your understanding while focusing your efforts where they'll count the most. Used by thousands of medical students each year to succeed on USMLE Step 1, Kaplan's official lecture notes are packed with full-color diagrams and clear review. The 7 volumes-Pathology, Pharmacology, Physiology, Biochemistry/Medical...

DNA testing and its forensic analysis are recognized as the "gold standard" in forensic identification science methods. However, there is a great need for a hands-on step-by-step guide to teach the forensic DNA community how to interpret DNA mixtures, how to assign a likelihood ratio, and how to use the subsequent likelihood ratio when reporting interpretation conclusions. Forensic DNA Profiling: A Practical Guide to Assigning Likelihood Ratios will provide a roadmap for labs all over the world...

The Second Edinburgh International Workshop was held in September, 1984 and took as its topic the coordinated regulation of gene expression. The intention of this series of workshops is to promote exchange of ideas and data between scientists and clinicians whose interests span molecular and cell biology, development and differentiation, oncology, and genetic and developmental pathologies. It is hoped that such interdisciplinary discussions may give rise to fruitful insights. The meetings are st...

Somatic cell genetics is an exciting and rapidly expanding field of research. Since descriptions of the major experimental techniques in the field are scattered throughout various journals and other publications, there is a real need for a single reference source for both established investigators and students in the field. In addition, technical reports are frequently abridged such that many researchers are discouraged from attempting to adopt the appropriate methodology. This book, therefore,...

The Fourth Course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held September 18-31, 1983 at the Ettore Majorana Center for Scientific Culture in Erice, Sicily. The subject of the Fourth Course, which was co-sponsored by national and international agencies, was "Structure and Function of the Genetic "Appara- tus. " Participants from 15 countries around the world attended the course. The study of the genetic apparatus is one of humanity's most...

Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians and graduate students. It discusses several genetic and epigenetic changes like DNA methylation, mutations, Single Nucleotide Polymorphisms (SNPs), DNA rearrangements, chromosomal remodeling, MSI (Microsatellite Instability) and Chromosomal Instability (CIN) in genitourinary cancers. It is split into 15...

A cutting-edge collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems a...

Stability testing is a critical piece of a drug development program that assesses a potential drug's shelf life and required storage conditions. Pharmaceutical Stability Testing: A Practical Guide provides a comprehensive guide to the approaches and regulations covering stability testing. The book helps pharmaceutical personnel organize and conduct drug stability tests by describing the many different aspects of drug stability programs, the different types of study that are required, and the app...

On the last day of August in the year 2020 two girls are born. Genetic science enables the long life of one of them to be happy and free of suffering; she finally dies in 2140. In stark contrast, genes fill the life of the other with discrimination and oppression, and after enduring much misery she dies young, in 2048. These 'future histories' of two individuals provide a striking opening to Genetic Destinies. In the chapters that follow, Peter Little discusses the reality of the power of gene s...

Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

Antisense technology is a powerful procedure that permits the controlled silencing of a specific gene for investigations of mRNA and protein function. This valuable text provides proven step-by-step protocols for antisense techniques in a range of different organisms and cell culture systems. In addition it discusses the potential benefits and problems for various antisense methods which complement gene knock-out experiments. The book includes antisense techniques such as: analysis of nucleic a...

In February 2001, two separate teams published the first working drafts of the entire human genome, marking an achievement that is certainly one of the seminal developments in our understanding of human biology. A grasp of the function of each gene will radically change how we diagnose and prevent diseases and adminster treatments. But the drive to turn the completed sequence into practical knowledge is fraught with complexity. This volume, a summary of the eponymous symposium, gives the student...

This is the ninth volume in a series dealing with induced lesions in laboratory animals. The information on pathology and toxicology documented in the series is an aid to scientific institutions, industry and government agencies charged with the safety testing of food, drugs and chemicals.

Genomic instability is a major threat to living organisms. To counteract the damaging effects posed by endogenous and environmental agents, such as chemicals or radiation, micro-organisms devote several percent of their genome to encode proteins that function in the repair and recombination of DNA. For many years, a relatively small group of scientists have carefully delineated the molecular mechanisms of these repair processes, using the simplest model systems available, namely Escherichia coli...

Get all the major facts in this affordable, pocket--sized, concise reference. Presents the latest research in transition factors important to the study of gene regulation and cell differentiation and its implications for biomedical investigation, particularly in cancer, gene therapy and developmental biology.