Essentials of Bioinformatics, Volume II
Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not...
From its founding in 1927 until its dissolution in 1945, the Kaiser Wilhelm Institute for Anthropology, Human Genetics, and Eugenics (KWI-A) in Berlin-Dahlem transgressed many a boundary; indeed, the transgression of boundaries was in a sense its raison d’être from the outset. Initially this applied to the boundaries within the disciplinary canon of the human sciences. Even from its basic conception, the institute, centered around the person of its founding director Eugen Fischer (1874– 1967), w...
Climate Change Impact on Livestock: Adaptation and Mitigation
This volume addresses in detail both livestock’s role in climate change and the impacts of climate change on livestock production and reproduction. Apart from these cardinal principles of climate change and livestock production, this volume also examines the various strategies used to mitigate livestock-related GHG emissions, and those which can reduce the impacts of climate change on livestock production and reproduction. Presenting information and case studies collected and analyzed by profess...
Prenatal Genetic Counseling
Prenatal Genetic Counseling: Practical Support for Prenatal Diagnostics, Decision-Making, and Dealing with Uncertainty provides a foundation for new research and a one-stop source for physicians, genetic counselors, psychologists, social workers, general practitioners, grief workers, translational researchers, and administrators seeking to work in the field of clinical genomics ethically and in full consideration of patients’ psychological well-being. Here, an international team of experienced c...
Gene-Gene and Gene-Environment Interaction in Complex Trait Genome Wide Association
The recent gene-mapping successes have opened up unparalleled opportunities for determining the relationship of genetic variation to health and disease. Thus the focus of genetic research has been shifting towards identifying genes that increase the risk for susceptibility to disease, particularly in the presence of some environmental agent. This special issue highlights and summarizes many of the new and exciting methodological advances in localizing such genes. Several of the world’s leaders...
Transcription Factors (Essential Data S.) (Human Molecular Genetics)
Get all the major facts in this affordable, pocket--sized, concise reference. Presents the latest research in transition factors important to the study of gene regulation and cell differentiation and its implications for biomedical investigation, particularly in cancer, gene therapy and developmental biology.
Deoxyribonucleic Acid and Mutagenesis
by E Friedberg, Graham Walker, and Wolfram Siede
This is a major revision and updating of the classic work in the field of DNA repair by Errol Friedberg published in 1985. The authors have extensively revised the original text and provided more than 4000 references to current primary research literature. In addition, there are four new chapters on mutagenesis. The book will serve as an important reference resource for all courses in DNA repair and mutagenesis, and for molecular biologists working in many areas of cancer research
Foreign DNA in Mammalian Systems
Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily "contaminated" with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract of all mammalian organisms is also constantly in contact with foreign DNA. This book investigates the phenomena and mechanisms invo...
A supplement for any genetics textbook, this guide gives students thorough instruction and practice for solving genetics problems. Using callout comments, the author walks students through the process of breaking down word problems by dissecting each sentence. At each significant point in the statement of a problem, students learn to evaluate the given data, think about how it fits into the larger picture, and analyze relationships that lead to a potential solution. Currently,How to Solve G...
Genetic Approaches to Developmental Neurobiology
The development of modern medicine has contributed to clarifying the etiology and treatment of various diseases as well as to improving public health and welfare, and basic biological research has discovered a great deal about the underlying mechanisms at work. However, there are still many diseases which remain mysterious and incurable, and biological processes which are still imperfectly understood. In order to promote research in medicine and biology, non-governmental funding, as well as gove...
Adenovirus Methods and Protocols (Methods in Molecular Biology, v. 21) (Methods in Molecular Medicine, #130)
A cutting-edge collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems a...
Retroviral Reverse Transcriptases (Molecular Biology Intelligence Unit)
by Simon Litvak
Telomeres and Telomerase (Methods in Molecular Biology, #1587)
John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible methods provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to n...
Sex Determination and Differentiation in Insects
Three conditions are essential for evolution: variation, heredity and time. Most animal species transmit genetic information through sexual reproduction in order to meet the first two conditions. The consequence for sexual reproduction is the need for (at least) two sexes with different reproductive roles. Consequently, evolutionary issues arise, such as differences in morphological and behavioral attributes between the sexes, which are reflected in the plethora of animal sex-determining systems...
Chromosome Analysis Protocols (Methods in Molecular Biology)
Clear step-by-step instructions provide you with all the techniques used in both classical and molecular cytogenetics. The emphasis is on the use of human material. Chapters feature methods used in the preparation of chromosomes and karyotyping, techniques for using DNA probes to analyze chromosomes, and in situ hybridization and immunocytochemical and methods to visualize DNA.
Pharmaceutical Stability Testing
Stability testing is a critical piece of a drug development program that assesses a potential drug's shelf life and required storage conditions. Pharmaceutical Stability Testing: A Practical Guide provides a comprehensive guide to the approaches and regulations covering stability testing. The book helps pharmaceutical personnel organize and conduct drug stability tests by describing the many different aspects of drug stability programs, the different types of study that are required, and the app...
Genomes 2 covers modern molecular genetics from the genomics perspective, incorporating major advances made in the past three years, including the sequencing of the human genome, characterization of genome expression and replication processes, and transcriptomics and proteomics. The text is richly illustrated with clear, easy-to-follow, full-color diagrams, which are downloadable from the book's website (www wiley.com/brown).
Molecular and Human Genetics (Integrated medical sciences)
by Prof PA Hoffee
Medical Molecular Genetics is one of eight books in the Integrated Medical Sciences (IMS) Series from Fence Creek Publishing. Designed for first- and second-year medical students, they are ideal for use as textbooks, course supplements, or board preparation. The books in the IMS Series focus on the integration of core biomedical concepts and provide insights into the application of basic principles and processes to clinical medicine.
DNA Repair and Recombination
Genomic instability is a major threat to living organisms. To counteract the damaging effects posed by endogenous and environmental agents, such as chemicals or radiation, micro-organisms devote several percent of their genome to encode proteins that function in the repair and recombination of DNA. For many years, a relatively small group of scientists have carefully delineated the molecular mechanisms of these repair processes, using the simplest model systems available, namely Escherichia coli...
Adenovirus Methods and Protocols (Methods in Molecular Medicine, #131)
Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study. In addition to updating and expanding important chapters from the first edition, the authors have added new chapters that address innovative, exciting areas of emphasis in Ad research, including Ad vector construction and use, real-time PCR, use of ne...