'A new book by John McLeod is always a treat and, like good qualitative research, takes the reader by surprise, and shows him or her something new. The revelation to me in this book is its focus on philosophy (rather than psychology) and on John's insistence that qualitative research is rooted in a mixture of phenomenology and hermeneutics. Those of us engaged in qualitative research are challenged to underpin our work with a deeper awareness of relevant philosophy with Chapters 2, 3 and 4 offer...
Using nontechnical jargon this extremely accessible reference is a practical guide to survival analysis techniques in diverse environments. Introduces basic statistical concepts and methods to construct survival curves and later develops them to encompass more specialized and complex models. Contains a copious amount of various authentic examples to facilitate understanding.
It is now accepted that the first cells derived from simpler "objects", and that their descendants became more and more complicated and ordered until their evolutionary transformation into modern cells, namely, cells endowed with the same basic structures and mechanisms as those existing today. Although the appearance of the first modern cells goes back at least two billion years, many scholars believe that it occurred almost four billion years ago. In that case, the Earth's formation, which too...
chapter 1 Time in the Classical and Medieval Worldviews From the Beginnings to the Pre-Socratic School Zeno's Time Arrow and Aristotle's Continuum 6 Time and Creation According to Saint Augustine 15 Time and Medieval Astronomy 18 20 Calendars and Clocks chapter 2 Time in the Worldview of Classical Physics 25 Absolute Time According to Newton 26 Relational Time According to Leibniz 30 Time in Classical Mechanics 31 Time in Kant's Epistemology 35 chapter 3 Relativistic Spacetime 43 Time in Special...
CRC Handbook of Laboratory Model Systems for Microbial Ecosystems, Volume II
by Julian.W.T. Wimpenny
These volumes present the main classes of useful laboratory model systems used to study microbial ecosystems, with emphasis on the practical details for the use of each model. The most commonly used model, the homogeneous fermenter, is featured along with linked homogeneous culture systems, film fermenters, and percolating columns. Additionally, gel-stabilized culture systems which incorporate molecular diffusion as their main solute transfer mechanism and the microbial colony are explained....
Somitogenesis (Advances in Experimental Medicine and Biology, #638)
We visualise developmental biology as the study ofprogressive changes that occurwithin cells, tissues and organisms themselves during their life span. A good exampleofa field ofdevelopmentalbiology in whichthis conceptis encapsulatedis thatofsomitogenesis. The somitewas identifiedas the primordialunit underlyingthe segmentedorganisationofvertebrates more than two centuries ago. The spectacular discoveries and achievements inmolecularbiologyin the last fifty years have created a gene-basedrevolut...
Programmed Cell Death in Protozoa (Molecular Biology Intelligence Unit)
Under the name of programmed cell death (PCD) are included diverse molecular mechanism of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa....
Medical Applications of Controlled Release (Routledge Revivals, #1)
First Published in 1984, this book offers a full, comprehensive guide into drug administration. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
For the convenience of research workers, particularly those with limited knowledge of embryology, we have put together a series of tables to enable rapid identification of specific stages of embryonic development in the more commonly used mammals. Because if its frequent usage the chick embryo is included this atlas.
Molecular Genetic Epidemiology (Principles and Practice)
This volume describes high-throughput approaches to a series of robust, established methodologies in molecular genetic studies of population samples. Such developments have been essential not only to linkage and association studies of single-gene and complex traits in humans, animals and plants, but also to the characterisation of clone banks, for example in mapping of genomes. Chapters have been written by developers or highly experienced end-users concerned with a diverse array of biological a...
Proteome Research: Mass Spectrometry (Principles and Practice)
Recent advances in large-scale DNA sequencing technology have made it possible to sequence the entire genome of an organism. Attention is now turning to the analysis of the product of the genome, the proteome, which is the set of proteins being expressed by a cell. Two-dimensional gel electrophoresis can be used to create cellular protein maps which give a quantitative and qualitative picture of the proteome. Mass spectrometry is the method of choice for the rapid large-scale idenfification of t...
Molecular Science of Fluctuations Toward Biological Functions
In this monograph, the importance of fluctuations for biological reactions is discussed from various points of view. Understanding the biological reactions at the molecular level is one of the major targets in many scientific fields, including not only basic biology but also physics, physical chemistry, and medical science. One of the key factors in the process is “fluctuation”. Thermal energy causes biological molecules to be in constant fluctuation even while they are carrying out their biolog...
MACPF/CDC Proteins - Agents of Defence, Attack and Invasion (Subcellular Biochemistry, #80)
This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the...
Proteins of the Nucleolus
This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells. The goal of this work is to provide special insight into the nucleolus of the past, present and future, as well its regulation, translocation, and biomedical function. A multitude of topics are introduced and discussed in detail, including nucleologenesis, nucleolar architecture, nucleolar targe...
Phosphoinositides I: Enzymes of Synthesis and Degradation (Subcellular Biochemistry, #58)
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidyl...
This book is an introduction to concepts needed in the different parts of the process of doing science. It includes topics that will help achieve clarity in the posing of scientific questions, the design of ways to answer the questions, and the methods to evaluate the results and effectively communicate scientific information. It will be useful to the professional or student in the practice of writing papers, books or journal articles and can be appliedto most any area of science that requires p...
Brain Development in Drosophila melanogaster (Advances in Experimental Medicine and Biology, #628)
The central nervous system (CNS) represents the organ with the highest struc- tural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one ofthe major chal- lenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfi...
Stress-Activated Protein Kinases (Topics in Current Genetics, #20)
To maximize the probability of survival, cells need to coordinate their intracellular activities in response to changes in the extracellular environment. MAP kinase cascades play an important role in the transduction of signals inside eukaryotic cells. In particular, stress stimuli result in the rapid activation of a highly conserved group of MAP kinases, known as SAPKs (Stress-Activated Protein Kinases). These kinases coordinate the generation of adaptive responses that are essential for cell s...
1 Introduction The prostate causes a signi?cant number of medical problems in the adult male, and the lower urinary tract symptoms are accepted as an unavoidable consequence of male aging. Most of these symptoms are mainly due to clinical benign prostatic hyperplasia (BPH), which is the most frequent benign tumor in the male, in- pendent of race or culture. On the other hand, cancer of the prostate shows an increasing incidence, being the second leading cause of death in men, after lung cancer....
The Extracellular Matrix: an Overview (Biology of Extracellular Matrix)
Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins,...
WHO Expert Committee on Biological Standardization
Drugs, Driving and Traffic Safety
Drugs, Driving and Traffic Safety gives a comprehensive overview of the effects of different medical conditions like neurological disorders, anxiety and depression and their pharmaceutical treatment on driving ability. In addition, the effects of alcohol and drugs of abuse are discussed. Leading experts present the different methodologies to examine effects of drugs on driving, and summarize the recent scientific evidence including epidemiological studies, roadside surveys, laboratory tests, dri...
Phase Transitions in Cell Biology
Phase transitions occur throughout nature. The most familiar example is the one that occurs in water – the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change. Practically magical, the ever-so-slight shift of temperature or pressure can induce an astonishing transition from one entity to another entity that bears little resemblance to the first. So "convenient" a feature is seen throughout the domains of physics and chemistry, and one is...