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Global attention in scientific, industrial, and governmental commUnItIes to traces of toxic chemicals in foodstuffs and in both abiotic and biotic environ- ments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to pro- vide in international communication the coherency essential for nonduplicative and current progress in a fi...

Dr. Neil Nathan introduces fresh insights, updated information, and vital medical breakthroughs in this second edition of his bestselling book. Millions of people are suffering from chronic illnesses that, unbeknownst to them, are the result of exposure to environmental toxins and infectious agents such as mold and Borrelia, which causes Lyme disease. Millions. Because the symptoms of these illnesses are so varied and unusual, many of these individuals have sought medical care only to be dismis...

This volume provides the reader with a comprehensive overview of the routine and special toxicologic assessments performed on pharmaceutical agents, chemicals, pesticides and consumer products. Toxicity testing procedures will be described emphasizing experimental design considerations (dose and species selection, toxicokinetic criteria) as well as regulatory guidelines and impacts of global harmonization efforts. The volume also provides insights into the risk assessment process in terms of eva...

Current concepts on mechanisms mediating chemically induced nephrotoxicity are rapidly evolving. This volume is focused on capturing this rapidly growing field by providing a comprehensive, state-of-the-art review of renal pathophysiology and toxicology, written by internationally recognized experts in the field. The first section of this volume is designed to provide the reader with the needed background information; including an overview of clinical nephrotoxicity, the anatomy and physiology o...

This volume deals with the enzymatic processes involved in the biotransformation of toxic and potentially toxic chemicals. The first section provides introductory material on general aspects of history, regulation, mechanism, inhibition, and stimulation of the enzymes in this group. The bulk of the volume is comprised of chapters dealing with the current status of enzymes involved in oxidation, reduction, hydrolysis, and conjugation of xenobiotic chemicals. Each chapter is organized to cover the...

The overall theme for the Congress is "Basic Science in Toxicology". This volume is a compliation of papers presented as plenary lectures and in symposia at the Fifth International Congress of Toxicology (ICT V) held under the aegis of the International Union of Toxicology and hosted by the British Toxicology Society. The conference was held in July 1989 and was attended by over 1000 delegates.

This text focuses on the biological interactions of sulphur compounds which arise specifically from the presence of the sulphur atom within the molecule. The book opens with introductory chapters on the chemistry and biology of sulphur, before tackling the field by introducing compounds which share a common chemical combination. In general, following a description of the uses and impact upon the biological field, specific chemical group characteristics are discussed together with the biological...

As part of a long-standing collaboration on nuclear nonproliferation, the National Academy of Sciences and the Russian Academy of Sciences held a joint workshop in Moscow in 2003 on the scientific aspects of an international radioactive disposal site in Russia. The passage of Russian laws permitting the importation and storage of high-level radioactive material (primarily spent nuclear fuel from reactors) has engendered interest from a number of foreign governments, including the U.S., in explor...

The potential impact of anthropogenic pollutants such as agrochemicals on the environment is of global concern. Increasing use of certain compounds can result in contamination of food, water and atmospheric systems and in order to combat this pollution it is important to be able to accurately monitor the short and long term effects.This book describes the latest aquatic species models used as indicators of the toxic effects of environmental pollutants, including models that have not routinely be...

The present work is the first major attempt at reviewing comprehensively all the available information about the environmental fate and behaviour of the xenobiotic chemicals.

AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable sem...

The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and ot...

The Science of Responding to a Nuclear Reactor Accident summarizes the presentations and discussions of the May 2014 Gilbert W. Beebe Symposium titled "The Science and Response to a Nuclear Reactor Accident". The symposium, dedicated in honor of the distinguished National Cancer Institute radiation epidemiologist who died in 2003, was co-hosted by the Nuclear and Radiation Studies Board of the National Academy of Sciences and the National Cancer Institute. The symposium topic was prompted by the...

This fascinating work features such topics as the relationships between iodine deficiency and goiter, fluorine deficiency and caries, selenium deficiency and muscular degeneration, mercury surplus and specific nerve diseases, cadmium surplus and kidney failure. This one-of-a-kind volume reveals discoveries which may be of importance in future preventive medicine for man and animals. It shows that the comprehensive progress in chemical analyses has established a valuable basis for determining man...

The major organs of the body are targets for chemically-induced effects in animals and humans. This book reviews the mechanisms of these toxic effects and the structure/functional changes which occur in the target organ tissues as a result.

Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effecti...

Provides up-to-date information on current technologies and practices in solvent substitution for those involved in handling, using or managing hazardous and toxic solvents, based on an international workshop held in 1990. Covers a wide range of solvent substitution activities: paint stripping, coating applications, printed circuit boards, metal cleaning, metal finishing, manufacturing, hardware and weapons production and maintenance, compliance monitoring, and process control monitoring.

Now in its fourth edition, this core text and standard reference in toxicology has once again been updated to incorporate the latest testing procedures and address new challenges faced by toxicologists. The author brings together more than 70 distinguished investigators to detail current testing procedures, offer guidelines on data interpretation and highlight major areas of controversy. The book deals with the methods of toxicology, as well as principles and agents. New chapters on exposure ass...

Lead covers the salient aspects of the chemistry of lead, its environmental impact, and its effects on health. The technical, economic and social importance of Lead, at the present time, is beyond all doubt. However, over the last few decades little attention has been given to its behaviour (the properties and applications of its compounds, the environmental distribution of these derivatives, and their impacts on living creatures), this book addresses that gap. It includes coverage of hist...

Maintaining its user-friendly approach, this new edition of a bestseller summarizes information necessary for the effective and efficient operation of an IACUC. The book covers training programs and discusses professional certifications for IACUC administrative and animal care staff. It provides pointers to principal investigators, discusses interactions between IACUCs and other compliance panels, and addresses occupational health and safety programs and the role they play in the overall animal...