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For critical care of laboratory rodents, there is a scarcity of sources for comprehensive, feasible, and response-oriented information on clinical interventions specific to spontaneous and induced models of disease. With the more complex cases that need critical care management, many treatment approaches to veterinary emergencies cannot be applied directly to the laboratory rodent. The first text of its kind devoted to the challenges of critical care management for laboratory rodents, Critical C...

Many of the toxic effects elicited by xenobiotics can be explained at the molecular level by their interaction with receptors or by disruption or interference with receptor-mediated signal transduction pathways. This volume describes molecular approaches and reviews of current research. It provides reviews of numerous research areas which are direc

Drug misuse and dependence is an ever evolving field of study, which has exploded over recent years owing to the advent of the internet. Due to the ever-growing number of young people using drugs recreationally and the privatisation of drug screening and detection services, there is the need to disseminate evidence-based information concerning the technology and methods available for studying this expanding field. Detection of Drug Misuse describes the current state-of-the-art techniques used fo...

This book discusses the findings of most of the active researchers in taxonomy, molecular biology, ecology, physiology and toxicology, as well as public health officials concerned with the apparent global epidemic of harmful, toxic, noxious and nuisance phytoplankton events in the sea. It should be of use to public health officials and organizations; coastal management specialists; international, national, regional and state agencies concerned with the sea and its resources; and aquaculturists.

Environmental toxicology is an interdisciplinary science, which integrates biology, microbiology, chemistry, engineering, environmental sciences, ecology and other sciences. Assessment of the environmental effects of chemicals is complicated as it depends on the organisms tested and involves not only the toxicity of individual chemicals, but also their interactive effects, genotoxicity, mutagenicity and immunotoxicity testing. Various stressors affect the environment sometimes showing synergisti...

Exposures at low doses of radiation, generally taken to mean doses below 100 millisieverts, are of primary interest for setting standards for protecting individuals against the adverse effects of ionizing radiation. However, there are considerable uncertainties associated with current best estimates of risks and gaps in knowledge on critical scientific issues that relate to low dose radiation. The Nuclear and Radiation Studies Board of the National Academies hosted the symposium on The Future of...

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overc...

First Published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited b...

Zebrafish are widely considered an excellent model system for vertebrate development. The embryo is transparent, thereby enabling visualization and use of labelling and transgenic approaches. Moreover, because of the ease of inducing new mutations in zebrafish and similarity with the human genome, this organism may be used effectively for disease studies. For example, mutant zebrafish are being utilized for testing drugs that will combat a range of human diseases, from Alzheimer's and cancer to...

Mustard gas is typically associated with the horrors of World War I battlefields and trenches, where chemical weapons were responsible for tens of thousands of deaths. Few realize, however, that mustard gas had a resurgence during the Second World War, when its uses and effects were widespread and insidious. Toxic Exposures tells the shocking story of how the United States and its allies intentionally subjected thousands of their own servicemen to poison gas as part of their preparation for che...

A contemporary survey of the industrial processes used to prepare meat, which covers freezing, cooking, preservation and comminuted products. Each section is supported by references to the technical literature. Emphasis is placed on qualities which make the product attractive to the consumer.

To be effective a drug must be Absorbed then Distributed to the site of action. It must also be Metabolised and Excreted without any measurable Toxicity (ADMET). This volume examines major ADMET issues, tools to measure these properties in vivo and in vitro and in-silico tools to predict and analyse effects. It concludes with a review of tools that can assist drug discovery in its early development stage.

Throughout human history, we have long encountered the combination of promise, risk, and uncertainty that accompanies emerging technologies. Nanotechnology is a recent example of an emerging technology that promises to drastically improve existing products as well as allow for creative development of new goods and services. This new technology also has its potential downsides. Industry, academia, and regulatory agencies are all working overtime to assess risks accurately while keeping up with th...