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Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are...

In May 2003, the Russian Academy of Sciences and the National Academies organized an international workshop in Moscow on the scientific issues relevant to the establishment and operation of an international spent nuclear fuel storage facility in Russia. Given the broad international interest in this topic, the academies organized a second international workshop on important issues that were not on the agenda or were not adequately discussed at the first workshop. These issues included internatio...

In 1943, as part of the Manhattan Project, the Hanford Nuclear Reservation was established with the mission to produce plutonium for nuclear weapons. During 45 years of operations, the Hanford Site produced about 67 metric tonnes of plutonium—approximately two-thirds of the nation's stockpile. Production processes generated radioactive and other hazardous wastes and resulted in airborne, surface, subsurface, and groundwater contamination. Presently, 177 underground tanks contain collectively abo...

The US Environmental Protection Agency Office of Radiation and Indoor Air asked the National Research Council to evaluate whether sufficient new data exist to warrant a reassessment of health risks reported in Health Effects of Exposure to Low Levels of Ionizing Radiations (BEIR V) in 1990. To respond to this request, the National Research Council assembled the Committee on Health Risks of Exposure to Low Levels of Ionizing Radiations. The work of the committee was conducted in what was called t...

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part...

The rapid expansion of the nanotechnology field raises concerns, like any new technology, about the toxicity and environmental impact of nanomaterials. This book addresses the gaps relating to health and safety issues of this field and aims to bring together fragmented knowledge on nanosafety. Not only do chapters address conventional toxicity issues, but also more recent developments such as food borne nanoparticles, life cycle analysis of nanoparticles and nano ethics. In addition, the authors...

Research on the study of membrane toxicity has advanced a great deal in a relatively short period of time, prompting scientists to re-examine the problems associated with carriers, receptors and reactors to toxic substances. This book presents current research on the responses of membranes to toxic sub- stances both by direct observation of macromolecules reacting with these substances and by inference from data on the bio- chemical responses of cells and cell fractions. Two basic areas of membr...

Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides val...

This reference handbook provides fully updated chemical, regulatory, health, and safety information on nearly 800 pesticides and other agricultural chemicals. The clear, consistent and comprehensive presentation of information makes Sittig's an essential reference for a wide audience including first responders, environmental and industrial health/safety professionals, the food industry, the agricultural sector and toxicologists. Detailed profiles are provided for each substance listed, includ...

This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air

The pathological and behavioral manifestations of alcoholism are caused by a number of biological factors, including genetic predisposition, metabolic alteration and cellular injury. In this issue, investigators explore novel mechanisms underlying alcohol-induced tissue injury, particularly in the liver and in the central nervous system. Special emphasis is placed on understanding ethanol's ability to enhance cellular signaling pathways and protein kinases, which are known to play an important...

Global attention in scientific, industrial, and governmental communities to traces of toxic chemicals in foodstuffs and in both abiotic and biotic environ ments has justified the present triumvirate of specialized publications in this field: comprehensive reviews, rapidly published progress reports, and archival documentations. These three publications are integrated and scheduled to pro vide in international communication the coherency essential for nonduplicative and current progress in a fiel...

Praise for the First Edition"This book is easy to read and has many informative illustrations…I would strongly recommend this book to those interested in a broad introduction to the care and use of laboratory guinea pigs as well as to laboratory animal technicians, managers, veterinarians and scientists who do not have direct access to large, well organized animal resource units with extensive library facilities."—John D. Young, Contemporary TopicsThe Laboratory Guinea Pig provides a compact and...

Following World War II, chemical companies and agricultural experts promoted the use of synthetic chemicals as pesticides on weeds and insects. It was, Pete Daniel points out, a convenient way for companies to apply their wartime research to the domestic market. In Toxic Drift, Daniel documents the particularly disastrous effects this campaign had on the South's public health and environment, exposing the careless mentality that allowed pesticide application to swerve out of control. The quest t...

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication.Non-Clinical Vascular Infusi...