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This book looks at the latest outbreak of Salmonella Typhimirum which started in September 2008. The illnesses peaked in December 2008, affecting consumers in 43 states. Though the illnesses have declined since the first announcement on 10 January 2009 that the suspected cause was peanut butter, they have not abated. The Salmonella strain has been linked to contaminated products from Peanut Corporation of America. As of January 29, 2009, there have been eight deaths and 550 illnesses linked to P...

The purpose of this series is to provide a resource for concise, detailed reviews of key aspects of the biochemistry of substances of abuse. This text presents pertinent research findings on various effects of drug and alcohol abuse by knowledgeable specialists in this field. Some biochemical changes considered include immunomodulation, altered disease resistance, membrane fluidity and functional modifications, teratogenic effects, and modifications of hormonal regulation and production with maj...

Designed for upper-level undergraduate and graduate-level courses, Forensic Toxicology: Mechanisms and Pathology introduces toxicology concepts from a forensic perspective. The book provides an understanding of the mechanistic basis of the action of drugs and toxins, addressing their physiologic and pathologic consequences on the affected organ system. It is this essential connection of toxicology to physiology and biological systems that provides the basis for the toxicologist to understand the...

Drug misuse and dependence is an ever evolving field of study, which has exploded over recent years owing to the advent of the internet. Due to the ever-growing number of young people using drugs recreationally and the privatisation of drug screening and detection services, there is the need to disseminate evidence-based information concerning the technology and methods available for studying this expanding field. Detection of Drug Misuse describes the current state-of-the-art techniques used fo...

The presence of chemicals in our environment is a subject of intense interest owing to the many potential adverse health effects to humans following exposure to these chemicals. The principles and practices of risk assessment are used to assess the associated health risks to provide a scientific and health basis for guidance or regulatory standards development and risk management decision making for public health protection. This book compiles, discusses, and presents cutting-edge research data...

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

In this third edition, the editors have accounted for the numerous changes in protocols for managing poison ingestions and have again provided an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals helps the reader understand why events occur and why a particular treatment is selected. Each chapter presents pertinent information on classes of toxic agents, their common sources and...

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has led to an abundance of scientific, medical, and commercial applications with unlimited potential.Pore-forming Peptides and Protein Toxins describes h...

This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposit...

5-Hydroxytryptamine-3 Receptor Antagonists provides a comprehensive, authoritative review of the topic featuring contributions by recognized leaders in the field. The book's three sections cover compound discovery and activity rationalization, the use of compounds for studying 5-HT3 receptors, and their applications to therapeutics. This book will be an important reference for oncologists, researchers working with the CNS and gastrointestinal disorders, and anyone working in the 5-HT field withi...

Phosphagen Kinases discusses phosphagen kinases and their substrates, and demonstrates that the role of the phosphagen-phosphagen kinase system is not limited to energy depositing functions. The book is unique in its complex biological, chemical, and physiological coverage of the family of related enzymes and phosphagen kinases. This book also emphasizes creatine and arginine kinases in the evolution of phosphagen kinases and provides information regarding biosynthesis, structure, physico-chemic...

Written in clear, simple language, this concise book introduces the lay person to the science of toxicology as it relates to daily living. The book provides a general overview of toxicology, presenting the facts and underlying principles needed by non-specialists for making decisions about potentially hazardous substances in everyday settings. Understanding Toxicology: Chemicals, Their Benefits and Risks will help you separate fact from fiction and better evaluate conflicting news reports on tox...

Volume 8 begins with a detailed description of the functional anatomy of the various regions and critical cells of the respiratory tract, from the nasal cavity to the gas exchange region. This section conveys the structural heterogeneity of the respiratory system and how it determines tissue and cellular targets for toxic agents. The next section describes functional and biochemical responses of the lungs to toxic insult and includes chapters on carcinogenic and developmental responses to chemic...

Volume 5 provides current knowledge regarding the intricacies of the immune system and the manner by which environmental agents can disrupt immune homeostasis and induce pathologies. The volume begins with an introduction to the field of immunotoxicology and an overview of the immune system. This is followed by a description of the cellular components of the immune system and how their development and reactivities can be modified. The architecture of the immune system is described as well as imm...

Neurotoxicology is among the fastest growing of the toxicological disciplines. Recent refinements of neuropathologic techniques, meticulous validation of behavioral tests, and introduction of the tools of molecular biology have led to rapid progress in our understanding of the mechanisms and consequences of neurotoxic injury. This volume is intended to provide the reader with an appreciation of the scope of approaches taken in the mechanistic study of neurotoxic agents. The volume's 31 chapters,...