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Contents: A.G. Gonzalez and J. Bermejo Barrera: Chemistry and Sources of Mono- and Bicyclic Sesquiterpenes from Ferula Species. - G. Prota: The Chemistry of Melanins and Melanogenesis. - H.J.M. Gijsen, J.B.P.A. Wijnberg, and Ae. de Groot: Structure, Occurrence, Biosynthesis, Biological Activity, Synthesis, and Chemistry of Aromadendrane Sesquiterpenoids. The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer...

Since the inception of this volume, the world's nancial climate has radically changed. Theemphasishasshiftedfromboomingeconomiesandeconomicgrowth totherealityofrecessionanddiminishingoutlook. Witheconomicdownturncomes opportunity,inallareasofchemistryfromresearchanddevelopmentthroughto productregistrationandriskassessment,replacementsarebeingsoughtforcostly time-consumingprocesses. Leadingamongstthereplacementsaremodelswithtrue predictivecapability. Ofthesecomputationalmodelsarepreferred. This v...

Find out what you’re taking with this fully updated pocket-sized guide to more than 2,500 prescription and over-the-counter drugs from Britain’s leading medical authority, the BMA. Jargon-free and easy-to-follow get all the vital information you need on today’s drugs fast. Learn how they work, what they treat, their risks, benefits and side effects, and how to use them safely and effectively. Plus find detailed descriptions and facts on 260 commonly used medicines including the latest on antic...

At the end of the initial meeting on Primary and Secondary Metabolism of Plant Cell Cultures at Schloss Rauischholzhausen, it was decided to convene similar events on a regular basis midway between the International Congress for Plant Tissue and Cell Cul ture. We felt it was necessary to bring representatives of the research teams working in this field together to assess progress as well as to discuss future directions. The Plant Biotechnology Institute of the National Research Council of Canada...

Using case studies of successful drug discoveries and launches, this book helps master the necessary knowledge of the drug discovery process. It includes pharmacology, drug metabolism, biology, drug development, and clinical studies. The introduction provides an overview of process, principles, and technologies and each chapter contains case studies that focus on one therapeutic target. It also offers stories from patients who have used the drugs covered as a way to illustrate the impact medicin...

A comprehensive collection of the applications of Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Electron-Spin Resonance (ESR). Covers the wide ranging disciplines in which these techniques are used:* Chemistry;* Biological Sciences;* Pharmaceutical Sciences;* Medical uses;* Marine Science;* Materials Science;* Food Science. Illustrates many techniques through the applications described, e.g.:* High resolution solid and liquid state NMR;* Low resolution NMR, especially im...

I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at th...

Discover herbal alternatives for the treatment of psychological disorders!Reliable and fact-filled, the Handbook of Psychotropic Herbs: A Scientific Analysis of Natural Treatments for Psychiatric Conditions offers psychiatrists, psychologists, counselors, physicians, and students in these fields a comprehensive review of the history, pharmacology, chemistry, and uses of medicinal herbs. A valuable resource for understanding today's unregulated herbal marketplace, this essential guide examines su...

Filled with strategies to minimize the adverse effects of injectable drugs, this book provides the scientific background and techniques required to evaluate parenteral formulations with respect to their potential to cause pain, irritation, and muscle damage. Using a unique, interdisciplinary approach, the book's editors and contributors represent the areas of pharmaceutics, physiology, anatomy, toxicology, and product formulation. The chapters cover topics such as muscle damage with injectables,...

The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan...

This volume comprises three reviews. The first describes isolation, structure determination, syntheses, and biochemistry of the low molecular weight compounds of the secretion of exocrine glands of termies with emphasis to pheromones and defensive compounds. The second review describes recent studies on isolation and structure elucidation of bioactive compounds involved in the life cycle and determination of the molecular mechanisms of the developmental events observed in higher plants. The thir...

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, includi...

Since ancient times the mistletoe plant has been used for healing diseases. Today mistletoe extract therapy is among the most thoroughly studied complementary treatments in Europe. Several studies and meta-analyses have shown it to be beneficial for cancer patients in terms of survival, improved quality of life and minimised side effects of cancer chemotherapy. This book gives an overview of the research on mistletoe therapy from antiquity to the present. Topics discussed include the cultural a...

Hardbound. In analytical chemistry and pharmaceutical technology attention is increasingly focussed on improving the quality of methods and products. This book aims at fostering the awareness of the potential of existing mathematical and statistical methods to improve this quality. It provides procedures and ideas on how to make a product or a method less sensitive to small variations in influencing factors. Major issues covered are robustness and stability improvement and ruggedness testing. Ge...

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you...

Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you...