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Provides expert, state-of-the-art insight into the current progress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era of personalized or precision medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinent molecular discoveries in the ca...

Nearly every cellular activity, such as cell growth, proliferation, protein synthesis and nuclear division, is regulated by protein phosphorylation/dephosphorylation on tyrosine residues as initiation events. Synchronization occurs through the interaction of protein tyrosine kinases and phosphatases. This book unveils signal pathways that connect extracellular signals with changes in the phosphorylation state of target proteins, allowing the co-ordinated and integrated modulation of mitogenic si...

A cutting-edge collection of readily reproducible methods for conducting research with adenoviruses, the premier and most widely used model in cell and molecular biology. The methods range from how to grow and titer adenoviruses and how to construct specific alterations in the adenovirus genome, to how to measure apoptosis induced by cells of the immune system, cytokines, and intrinsic apoptosis effectors. In addition, there are methods to study transcription and splicing with in vitro systems a...

If stories are medicine, then this collection will help keep hopes up and spirits alive on the road to recovery. Readers will applaud the bravery of 50 exceptional survivors as they tell their unique experiences with breast cancer. Every breast cancer survivor has a different story, but they all have one thing in common: courage. From dealing with diagnosis to undergoing chemotherapy, facing hair loss and possibly the loss of a breast, these fearless women undergo more than anyone ever should. T...

Written by oncology experts with over 20 years of experience, 100 Questions and Answers About Lymphoma, Second Edition provides authoritative answers to your questions on lymphoma. Featuring the information you need in one concise, easy-to-read volume, 100 Questions and Answers About Lymphoma, Second Edition is an invaluable resource for newly diagnosed patients, survivors, friends or relatives of either. Now, in its Second Edition, this newly updated text features information on the latest, cut...

Hearing the words "You have cancer" can be devastating-some cancer patients even say that the emotional pain and loss of certainty from hearing this are worse than the pains from the cancer, surgeries, radiation, chemotherapy, and other treatments. This is the intimate journey of a melanoma and breast cancer survivor who honestly, and sometimes even humorously, shares her own story and offers supportive emotional tools to help people diagnosed with cancer, and their loved ones and caregivers, wo...

This book tells the story of the life of one man who suffered from neurofibromatosis. Through horrible physical deformities which were almost impossible to describe, Joseph Merrick spent much of his life exhibited as a fairground freak until even 19th century sensibilities could take it no more. Hounded, persecuted and starving he ended up being rescued by the distinguished surgeon Frederick Treves. To Treves's surprise he discovered, during the course of their friendship, that lurking beneath t...

Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertiseGreater emphasis throughout on the clinical importance an...

I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at th...

Cellular Immune Mechanisms and Tumor Dormancy features the work of internationally recognized experts from various disciplines as they discuss the phenomenon of tumor dormancy in humans. Animal models are described in which cellular and molecular components of the immune control of dormancy have been identified, and the relevance of these models to human cancer patients is recognized. Data derived from studies of organ transplantation, adjuvant chemotherapy, radiotherapy, anaesthesia, surgery, a...

Pathologie, Klinische Zytologie, Histochemie, Onkologie, Hamatologie, Medizinische Informatik Das Buch beschreibt die Grundlagen und wichtige Anwendungen stereologisch-morphometrischer Methoden sowie der rechnergestutzten Bildverarbeitung auf dem Gebiet der klinischen Zytologie und Histopathologie. Dabei liegt der Schwerpunkt auf dem Gebiet der Histometrie, einer sehr jungen Disziplin, in der bisher eher stereologische interaktive Methoden Anwendung fanden. Nicht nur die verschiedenen Messverfa...

First published in 1988: This comprehensive set is crucial to the basic understanding of the immune system and is an essential component of the design and implementation of improved immunization strategies. Contains authoritative reviews of cell migration research and addresses the is-sues of lymphocyte recirculation leading to inductive interactions, and the subsequent migration and homing of effector cells generated from these responses. Systemic migration of cells from the central and periphe...