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In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offe...

Using case studies of successful drug discoveries and launches, this book helps master the necessary knowledge of the drug discovery process. It includes pharmacology, drug metabolism, biology, drug development, and clinical studies. The introduction provides an overview of process, principles, and technologies and each chapter contains case studies that focus on one therapeutic target. It also offers stories from patients who have used the drugs covered as a way to illustrate the impact medicin...

Applications of Microdialysis in Pharmaceutical Science focuses on the use of microdialysis in drug evaluation for different organs and tissues and pharmacokinetics. Introducing the basic principles of microdialysis, the book also covers quantification and validation, analytical considerations, pharmacodynamic studies, pharmacokinetics, clinical aspects, and other applications of microdialysis. Ideal for analytical chemists, pharmacists, and pharmacologists, this book uses easy-to-understand mo...

An essential, up-to-date guide to the design of studies and selection of the correct QoL instruments for observational studies and clinical trials. Quality of Life (QoL) outcomes or Person/Patient Reported Outcome Measures (PROMs) are now frequently being used in randomised controlled trials (RCTs) and observational studies. This book provides a practical guide to the design, analysis and interpretation of studies that use such outcomes. QoL outcomes tend to generate data with discrete, bounded...

Der Ratgeber erklart einfach und verstandlich das Krankheitsbild, deutet moegliche Fruhwarnsignale oder Symptome anhand von Beispielen, und zeigt den Weg zur gesicherten Diagnose mit Vorstellung der unterschiedlichen medizinischen Verfahren. Zudem werden die therapeutischen Moeglichkeiten samt Selbsthilfe der Patienten vorgestellt. Kribbeln und Stechen, brennende Schmerzen, aber auch Taubheit in bestimmten Koerperteilen koennen erste Anzeichen fur eine Polyneuropathie sein. Gerade in den letzten...

This new volume in the Encyclopaedia of Sports Medicine series, published under the auspices of the International Olympic Committee, delivers an up-to-date, state of the art presentation of the scientific aspects of conditioning, injury prevention, and competition. The book covers the key areas of scientific knowledge in sport and is divided into: physiology and biochemistry; nutrition; anthropometry; immunology; cell biology; biomechanics, engineering and ergonomics; psychology; pharmacology; l...

Offering an authoritative overview of all infection management protocols currently utilized by infectious disease specialists, geriatricians, and infection control practitioners, this Second Edition examines current strategies to diagnose, treat, control, and prevent common infectious diseases in long-term care geriatric facilities. Covering a wide

While the health effects of many aspects of life, from diet to marital status, have been extensively explored, little study has been made of the health effects of work. Covering such topics as on-the-job dangers, the role of unions in worker protection, and occupational health in both developed and developing countries, this collection of articles conclusively demonstrates the negative impact that neglect of citizens' working lives has on pubic health. With more Americans dying each year from jo...