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In this unique book, experts describe practices applicable to the large-scale processing of biotechnological products. Beginning with processing and bulk storage preservation techniques, the book provides strategies for improving efficiency of process campaigns of multiple products and manufacturing facilities for such processing techniques. Large-scale chromatography for the purification of biomolecules in manufacturing and lyophilization of protein pharmaceuticals are discussed. Includes a cas...

Living longer is closer than we think. Even before the first person set off to find the Fountain of Youth, we were searching for a way to live longer. But promises of life extension have long reeked of snake oil, and despite our wishful thinking—not to mention the number of vitamins we pop—few of us believe we’ll live to see one hundred, much less set a longevity record. But now scientists are closing in on true breakthroughs in anti-aging. Compounds that dramatically extend the health spans...

Computer-assisted Drug Design (CADD) reviews the use of computational methods and how these can aid the drug discovery process. Experts review in-silico approaches for the design and improvement of drug properties. Techniques for modelling, analysing and optimization of properties including potency, selectivity and ADMET are presented. Methods discussed include the Quantitative Structure Activity Relationship (QSAR), ligand and structure-based, lead discovery and new directions. Ideal for studen...

In this book, Phelps and Parente explore the US health care system and set out the case for its reform. They trace the foundations of today’s system, and show how distortions in the incentives facing participants in the health care market could be corrected in order to achieve lower costs, a higher quality of care, a higher level of patient safety, and a more efficient allocation of health care resources. Phelps and Parente propose novel yet economically robust changes to US tax law affecting...

Finally, the real story about corporate America with its increased reliance on consultants. Since the 1990s, consulting solutions have become the de facto standard for solving business problems and providing cover for corporate decision makers. This is not the typical CEO whitewash, or business management primer. Steve Romaine offers a view never before shared with management or stockholders as he takes a hired gun's journey beginning at the outside looking in, and ending at the pinnacle of a co...

The pandemic imposed significant changes in the performance of many companies in different industries. It has led to greater agility in business models, new forms of interaction with all stakeholders and new points of contact, and a much greater centrality of the digital, the new digital skills of managers and entrepreneurs, the implications of COVID in the modeling of the business fabric, in the configuration of the markets and in the expectations of consumers that need to be answered. It empha...

AMERICAN CARTEL is an unflinching and deeply documented dive into the culpability of the drug companies behind the staggering death toll of the opioid epidemic. It follows a small band of DEA agents led by Joseph Rannazzisi, a tough-talking New Yorker who had spent a storied thirty years bringing down bad guys; along with a band of lawyers, including West Virginia native Paul Farrell Jr., who fought to hold the drug industry to account in the face of the worst man-made drug epidemic in American...