Fuensanta Nieto has worked as an architect since graduating from the Universidad Politecnica de Madrid and the Graduate School of Architecture and Planning at Columbia University in New York in 1983. She is a founding partner of Nieto Sobejano Arquitectos and a professor at the Universidad Europea de Madrid. Fuensanta Nieto lectures on architecture and participates in juries and symposia at various institutions around the world. From 1986 to 1991 she was co-director of the architectural journal ARQUITECTURA, published by the Colegio Oficial de Arquitectos de Madrid.