Kenneth P. O'Donnell (1924-1977) was born in Worcester, Massachusetts, in March 1924, and was the founding member of what the press dubbed the "Boston Irish Mafia," which also included David F. Powers and Larry O'Brien. His father was the famed Holy Cross football coach Cleo O'Donnell. Kenneth O'Donnell became a bombardier pilot, a war hero, and a graduate of Harvard University, where he played football with Robert F. Kennedy. He was later inducted into Harvard's football hall of fame, and many of his records remain unbroken to this day.

O'Donnell met John F. Kennedy in 1946, and through his relationship with Bobby Kennedy, became John Kennedy's top political aide from that point forward. During the 1960 political campaign, he worked hand in glove with Jack and Robert Kennedy as they developed the "Kennedy machine" and drove it to victory.

Once in the White House, John Kennedy named O'Donnell special assistant and appointment secretary; nobody got to see Jack Kennedy without first going through O'Donnell. He was with Kennedy that fateful afternoon in Dallas, Texas, in 1963.

After Kennedy's death, O'Donnell stayed on for one year in the same role with then-president Lyndon Johnson. He also became executive director of the Democratic National Committee and is credited with helping to create the modern DNC. He later left Washington to return to Boston, where he ran for governor in 1966, losing in a very tight race. Later, as a political consultant, he worked with senators Robert F. Kennedy and Hubert Humphrey. He remained close to Jacqueline Kennedy Onassis throughout his life, helping her to establish the John F. Kennedy Presidential Library and Museum. He also remained a close friend and advisor to Bobby Kennedy. O'Donnell collaborated with Dave Powers on the now-classic memoir Johnny, We Hardly Knew Ye. O'Donnell was later made famous in the film Thirteen Days, in which his relationship with Jack and Bobby Kennedy is accurately portrayed by Kevin Costner. O'Donnell died in September 1977 at the age of fifty-three.