Maud Fuller was the daughter of a Baptist minister, She grew up with three sisters in a parsonage. The family moved to Sioux Falls, South Dakota, to Newburg, New York, and finally to Scranton, Pennsylvania. As a child, she loved picture books and to draw. After graduating from Vassar College she studied at the New York School Of Fine And Applied Art. Her first job was in the art department at the International Art Service, an advertising firm, where she met her husband, Miska Petersham.

The Petershams began illustrating books together, at first only for other authors. In 1929 they wrote and illustrated their first book, Miki, about their son. In 1946, the couple received the Caldecott Medal for The Rooster Crows. Often they traveled to foreign lands such as Holland, Greece, Germany, and Palestine to do research for their books.

The Petershams wrote and illustrated 60 books for children and illustrated 100 by other authors.