Kate Wilhelm's first novel was a mystery, published in 1963. Over the span of her career, her writing has crossed over the genres of Science Fiction, Speculative Fiction, fantasy and magical realism; psychological suspense, mimetic, comic, and family sagas, a multimedia stage production, and radio plays. Her works have been adapted for television and movies in the United States, England, and Germany. Wilhelm's novels and stories have been translated to more than a dozen languages. She has contributed to Quark, Orbit, Magazine of Fantasy and Science Fiction, Locus, Amazing Stories, Asimov's Science Fiction, Ellery Queen's Mystery Magazine, Fantastic, Omni, Alfred Hitchcock's Mystery Magazine, Redbook, and Cosmopolitan.

Wilhelm and her husband, Damon Knight (1922-2002), also provided invaluable assistance to numerous other writers over the years. Their teaching careers covered a span of several decades, and hundreds of students, many of whom are famous names in the field by their own rights today. They helped to establish the Clarion Writer's Workshop and the Milford Writer's Conference. They have been the guests of honor and panelists at numerous conventions around the world. Wilhelm continues to host monthly workshops, as well as teach at other events. She is an avid supporter of local libraries and participates in fundraisers when she is able to.