Jackie Estacado, a mob hitman possessing a mysterious, melevolent force known as the Darkness, and New York Police Detective Sara Pezzini, wielding an equally mysterious weapon, the Wtichblade, are abducted and trapped in a realm of illusory violence and bottomless time. Forming an unsteady alliance, they rip through layers of false realities to discover that they're imprisoned on a huge, living spacecraft high in Earth's orbit - an ever-changing prison ship controlled by the mind of a madman. Their fellow inmates are swarms of Aliens and a female Predator.