De Gruyter Textbook
5 total works
Suspension Concentrates is a survey into the theory of the formulation and stabilization of suspensions, elaborating on the breaking of aggregates and agglomerates and the role of dispersing agents on flocculation and electrostatic and steric stabilization. Practical analysis by rheology is discussed. Suspension Concentrates is ideal for research scientists and Ph.D. students investigating chemistry, chemical engineering and colloidal science.
General introduction - Definition of nanodispersions (nanosuspensions, nanoemulsions, swollen micelles or microemulsions, liposomes and vesicles) and their size range. General description of their colloid stability. Main advantages of nanodispersions and their industrial applications.
Preparation of nanosuspensions by top-up process - Nucleation and growth and control of particle size distribution. Factors determining the formation of narrow particle size distribution. Role of surfactants and polymers. Preparation of nano-polymer colloids (lattices) by emulsion and dispersion polymerization. Factors affects the stability of nanosuspensions.
Preparation of nanosuspensions by bottom down process - Dispersion of preformed particles in liquids and the need of a wetting agent. Break-up of aggregates and agglomerates by application of high speed stirrers. Reduction of particle size by application of intense energy (microfluidization or bead milling). Maintenance of the colloid stability of the resulting particles. Reduction of Ostwald ripening.
Industrial applications of nanosuspensions - Application in pharmacy to enhance bioavailability, Application in sunscreens for UV protection. Application in paints and coatings.
Preparation of nanoemulsions by the use of high pressure homogenisers - Principles of emulsion formation and the role of the emulsifier. Selection of emulsifiers. Methods of emulsification and prevention of coalescence during emulsification. Origin of colloid stability of nanoemulsions. Prevention of Ostwald ripening
Low energy methods for nanoemulsion preparation - The phase inversion composition method and the role of mixing the surfactant with oil and water. The phase inversion temperature method for preparation of nanoemulsions. Preparation of nanoemulsions by dilution of microemulsions.
Practical examples of nanoemulsions and their industrial application - Nanoemulsions based on non-ionic surfactants and the role of the hydrophilic-lipophilic balance. Effect of oil solubility on the stabilityof nanoemulsions. Nanoemulsions based on polymeric surfactants. Applications in pharmacy and cosmetics.
Swollen micelles or microemulsionsDefinition of microemulsions and their size range. Thermodynamic definition of microemulstions. Theories of microemulsion formation and stability. Characterisation of microemulsions using scattering, conductivity and NMR rechniques.
Formulation of microemulsions and their industrial applications - Distinction between microemulsions and macroemulsions. Formulation of oil/water and water/oil microemulsions. Selection of emulsifiers for microemulsions. Application of microemulsions in tertiary oil recovery.
Liposomes and vesicles - Formation of multilamellar lipid layers (liposomes) by dispersion of lipids in water. Formation of unilamellar vesicles by sonication of the liposomes. Factors responsible for stabilisation of liposomes and vesicles. Use of block copolymers to enhance the stability of vesicles. Applications of liposomes and vesicles in pharmacy and cosmetics.
Preparation of nanosuspensions by top-up process - Nucleation and growth and control of particle size distribution. Factors determining the formation of narrow particle size distribution. Role of surfactants and polymers. Preparation of nano-polymer colloids (lattices) by emulsion and dispersion polymerization. Factors affects the stability of nanosuspensions.
Preparation of nanosuspensions by bottom down process - Dispersion of preformed particles in liquids and the need of a wetting agent. Break-up of aggregates and agglomerates by application of high speed stirrers. Reduction of particle size by application of intense energy (microfluidization or bead milling). Maintenance of the colloid stability of the resulting particles. Reduction of Ostwald ripening.
Industrial applications of nanosuspensions - Application in pharmacy to enhance bioavailability, Application in sunscreens for UV protection. Application in paints and coatings.
Preparation of nanoemulsions by the use of high pressure homogenisers - Principles of emulsion formation and the role of the emulsifier. Selection of emulsifiers. Methods of emulsification and prevention of coalescence during emulsification. Origin of colloid stability of nanoemulsions. Prevention of Ostwald ripening
Low energy methods for nanoemulsion preparation - The phase inversion composition method and the role of mixing the surfactant with oil and water. The phase inversion temperature method for preparation of nanoemulsions. Preparation of nanoemulsions by dilution of microemulsions.
Practical examples of nanoemulsions and their industrial application - Nanoemulsions based on non-ionic surfactants and the role of the hydrophilic-lipophilic balance. Effect of oil solubility on the stabilityof nanoemulsions. Nanoemulsions based on polymeric surfactants. Applications in pharmacy and cosmetics.
Swollen micelles or microemulsionsDefinition of microemulsions and their size range. Thermodynamic definition of microemulstions. Theories of microemulsion formation and stability. Characterisation of microemulsions using scattering, conductivity and NMR rechniques.
Formulation of microemulsions and their industrial applications - Distinction between microemulsions and macroemulsions. Formulation of oil/water and water/oil microemulsions. Selection of emulsifiers for microemulsions. Application of microemulsions in tertiary oil recovery.
Liposomes and vesicles - Formation of multilamellar lipid layers (liposomes) by dispersion of lipids in water. Formation of unilamellar vesicles by sonication of the liposomes. Factors responsible for stabilisation of liposomes and vesicles. Use of block copolymers to enhance the stability of vesicles. Applications of liposomes and vesicles in pharmacy and cosmetics.
Formulations starts with a general introduction, explaining interaction forces between particles and droplets, self-assembly systems, polymeric surfactants and nanoemulsions. The second part covers the industrial examples ranging from foams, soaps over to hair care, sunscreen and make-up products. Combines information needed by formulation chemists as well as researchers in the cosmetic industry due the increasing number of products.
Surfactants are surface active agents, molecules that have a significant role in emulsions, suspensions, and foams. They find widespread application in personal care, cosmetics, pharmaceuticals, agrochemicals and the food industry. The main objective of this graduate level textbook is to present an overview of the classification, physical properties, phase behavior, their effects and applications of surfactants, e.g. as emulsifiers, foam stabilizer, in nano- and microemulsions and as wetting agents.
Polymeric Surfactants covers the structure and stability origins of these highly useful surfactants. Adsorption and solution properties in emulsions are discussed based on their underlying thermodynamics and kinetics. Research scientists and Ph.D. students investigating chemistry, chemical engineering and colloidal science will benefit from this text on polymeric surfactants and their value in preparation and stabilization of disperse systems.