UCLA Symposia on Molecular and Cellular Biology, New

3 total works

Frontiers of Nuclear Magnetic Resonance in Molecular Biology

by David Live and etc.

Published 1 February 1990

This volume examines the application of NMR techniques to molecular biology, including gene cloning and expression, site- specific mutagenesis, and biosynthetic isotopic labelling. It describes the broad-ranging applications of NMR techniques to the elucidation of structures at atomic resolution for moderately large systems. Investigators from a variety of disciplines cover the analysis of conformation, dynamics and interactions for a variety of molecules, including DNA, RNA, carbohydrates, peptides and proteins. Throughout the text, the contributors demonstrate the success of multi-dimensional NMR studies of biopolymers in solution. The book also examines possible NMR approaches for investigating systems where the molecule of interest does not reorient rapidly in solution. These systems possess molecules in the crystalline or hydrated solid state, part of supramolecular structures in solution, or are simply too large to reorient.

Structured and Organizational Aspects of Metabolic Regulation

by Paul A. Srere and etc.

Published 1 March 1990

"Structural and Organizational Aspects of Metabolic Regulation" offers as a common thread for its collection of multidisciplinary studies the evolutionary pressures that have produced protein interactions necessary for coherent metabolic pathways - in both energy transformations and information processing. The book reports on significant advances in the area of metabolic control, investigating theories that now include interacting enzymes, the concept of flux control and the knowledge that single pacemaker enzymes are rarely found in metabolism. New methods are highlighted, such as the use of anti-idiotypic antibodies, electrophoresis in the presence of immobilized enzymes and the use of molecular genetics in the study of metabolic regulation.

Developmental Biology

by Eric H. Davidson and etc.

Published 1 April 1990

This work examines rules, system properties and mechanisms underlying developmental gene regulation in a broad range of organisms. It covers the thoughts and theories, experimental inventions, strategies and successes of recent investigations into developmental processes in organisms ranging from yeast and fungi to higher eucaryotes. Some of the specific topics covered include: calcium, cell cycle control, the role of protein kinase C in progesterone-induced maturation, molecular studies on mesoderm induction, mechanism of effector lineage commitment in T lymphocytes, and mating pheromone signal transduction in yeast.