Microarray Analysis of the Physical Genome (Methods in Molecular Biology, #556)
In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine met...
Die Autorin analysiert grundlegende Begrifflichkeiten, die in der normativen Argumentation zur grünen Gentechnik verwendet werden, und liefert damit eine philosophisch fundierte Argumentationsgrundlage. Sie geht von der Annahme aus, dass Begriffe wie z. B. Lebewesen‚ (natürliche) Art oder Gen in verschiedenen Bedeutungsnetzen unterschiedlich konnotiert sind und daher nicht kontextunabhängig definiert werden können. Die Begriffsklärung ist notwendige Voraussetzung, um zu einer angemessenen Bewert...
This text is divided into four parts. The first part discusses Mendellian genetics, covering: the basic principles of Genetics-Mendel's laws; linkage and crossing over; chromosome mapping; sex linked inheritance; sex determination; population genetics; and extrachromosomal inheritance and human genetics. The chapters of the first part all include problems with examples of solutions. The second part deals with molecular genetics which includes modern discoveries on DNA and gene action, and it dis...
The Evolutionary Synthesis
Biology was forged into a single, coherent science only within living memory. In this volume the thinkers responsible for the "modern synthesis" of evolutionary biology and genetics come together to analyze that remarkable event. In a new Preface, Ernst Mayr calls attention to the fact that scientists in different biological disciplines differed considerably in their degree of acceptance of Darwin's theories. Mayr shows us that these differences were played out in four separate periods between 1...
Search for New Genes
Recent progress in molecular biology and biotechnology is impacting the life sciences as well as the lives of people in unprecedented ways. Plant genetic transformation and molecular marker technologies have led to a paradigm shift in plant genetic resource management and crop improvement. Granting patent protection to genes has not only provided incentive for gene discovery and placed monetary value on germplasm resources, but also raised concerns about ownership and access to genetic resources...
From the author of the acclaimed The Epigenetics Revolution (`A book that would have had Darwin swooning' - Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions - 98% of the human genome - were dismissed as `junk'. But in recent years researchers have discovered that variations in this...
Evolution of Matter, The: From the Big Bang to the Present Day Earth
by Jan Kramers and I N Tolstikhin
Textbook of Animal Genetics and Breeding
Animal breeding and genetics is the branch of science concerned with maximizing desirable genetic traits in domesticated animals. The study of animal genetics involves topics such as gene expression, color genetics and animal breeding. Animal genetics focuses on various aspects of animal heredity, or the passing of traits from one generation to the next. The field encompasses topics such as genetic variability, genetic testing, and animal breeding. Animal geneticists have identified elements wit...
The Cytokine Factsbook and Webfacts (Factsbook)
by Katherine A Fitzgerald
Cytokines are chemical messengers produced by virtually all the cells in our bodies, and effect changes in cellular behavior that are important in a number of physiological processes, including reproduction, growth and development, and injury repair. While many different cytokines have been identified, their individual functions are only partly known. In some cases, one cytokine can interact with a variety of different cell types and elicit different responses from each cell. In other cases, dif...
Eukaryotic Transcription Factors
by Professor of Molecular Pathology Director Windeyer Institute of Medical Sciences David Latchman
Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromati...
Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases (Laboratory Techniques in Biochemistry and Molecular Biology)
This book offers a wide ranging and review of cutting edge developments along with tried and tested methods for isolation, resolution and quantification of inositol phospholipids and inositol polyphosphates in both cells and tissues. It includes detailed and rigorous methodology for identification of molecular species of inositol phospholipids, including their phosphates and glycans, with numerous examples of specific applications. Wherever available, both chromatographic and mass spectrometri...
Development of Sea Urchins, Ascidians, and Other Invertebrate Deuterostomes: Experimental Approaches (Methods in Cell Biology)
This book provides a practical guide to experimental methods for studying the development of invertebrate deuterostomes, such as sea urchins, ascidians, hemichordates, and amphioxus. These model organisms are of contemporary and historical importance to the study of developmental biology, particularly genomic research. The chapters provide detailed experimental protocols that cover a broad range of topics in modern experimental methods. Topics covered range from rearing embryos to the care of ad...
Nonlinear Physics of DNA (Wiley Series in Nonlinear Science)
by Ludmila V. Yakushevich
The first edition of this book was the first on the physics of DNA to go beyond the simple (simplified) 'linear' approach, and it has since been found that the inclusion of nonlinear effects leads to a significantly improved interpretation of experimental data. This new edition naturally retains this approach, but has been completely revised, updated and expanded to cover recent developments. Beginning with introductory chapters on DNA structure and dynamics, the book also includes a comparison...
Approaches to Autoimmune Diseases Using Epigenetic Therapy
by Trygve Tollefsbol
Emerging Role of Epigenetics in Human Neurodevelopmental Disorders
by Trygve Tollefsbol