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Vitamin D kann in der Haut durch die UV-B-Strahlung der Sonne gebildet sowie über bestimmte Lebensmittel und Supplemente zugeführt werden. Die aktive Vitamin-D-Form ist ein Steroidhormon mit Wirkungen in einer Vielzahl von Geweben. Ein Vitamin-D-Mangel ist in Deutschland weit verbreitet. Es gibt eine Reihe von Risikogruppen, vor allem aufgrund unzureichender kutaner Synthese. Neben den klassischen Vitamin-D-Mangelerkrankungen Rachitis und Osteomalazie ist ein Vitamin- D-Mangel vermutlich auch ei...

Provides the latest information on imaging technologies and transdermal delivery in skin disorders This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin condit...

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and t...

Halogenated organic compounds constitute one of the largest groups of environmental chemicals. The industrial production of new halogenated organic compounds has increased throughout the last century peaking in the 1960s, and continuing in widespread use today. Organohalides are integral to a variety of industrial applications, including use as solvents, degreasing agents, biocides, pharmaceuticals, plasticizers, hydraulic and heat transfer fluids, and intermediates for chemical synthesis, to na...

Environmental stresses represent the most limiting factors for agricultural productivity worldwide. These stresses impact not only current crop species, they are also significant barriers to the introduction of crop plants into areas that are not currently being used for agriculture. Stresses associated with temperature, salinity and drought, singly or in combination, are likely to enhance the severity of problems to which plants will be exposed in the coming decades. The present book...

Phosphorylation is the addition of a phosphate (PO 4 ) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes, causing or preventing the mechanisms of diseases such as cancer and diabetes. This book shows how to use mass spectrometry to determine whether or not a protein has been correctly modified by the addition of a phosphate group. It also provides a combination of detailed, step-by-step methodology for phosphoproteomic sample preparation,...

The contemplation of truth and beauty is the proper object for which we were created, which calls forth the most intense desires of the soul, and of which it never tires -Hazlitt In his Nobel lecture Purcell commented that when he saw snow in New England after the discovery of NMR, it appeared like "heaps of protons quietly precessing in earth's magnetic field. " If he were to make the comment in the context of how NMR is being used today, he could have conjured up an image of hydrogen, carbon,...