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Accurate molecular structures are vital for rational drug design and for structure-based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding.

Kary Mullis was awarded a Nobel Prize for inventing the PCR technique more than a decade ago in 1993. Since its "discovery", multiple adaptations and variations of the standard PCR technique have been described. This publication aims to provide the reader with a guide to the standard PCR technique and its many available variants, with particular emphasis being placed on the role of these PCR techniques in the clinical diagnostic laboratory (the central theme of this book).

Wahrend der letzten 20 Jahre hat sich dank der zunehmenden Verbreitung von Vierkreis-Diffraktometern und der enormen Steigerung der Computerlei- stung die Methode der Kristallstrukturbestimmung mittels Roentgenbeugung lawinenartig ausgebreitet. Wegen ihrer hohen Aussagekraft und Genauigkeit ist sie zu einem der wichtigsten Werkzeuge in der chemischen Grundlagenfor- schung geworden, in der anorganischen wie der organischen Chemie. Obwohl die Kristallographie in der Ausbildung der Chemiestudenten...

As in other scientific fields, the importance of boundary areas in wood research, such as that between lignin chemistry and hemicellulose chemis- try, continues to increase. Although the utilization of individual wood components has advanced to an appreciable extent, research into oligo- merie or polymerie compounds of two or more different components has made little progress. By contrast, in other fields, glycoproteins and pro te- oglycans have been found to form biochemical active centers in e...

X-ray crystallography has been a vital method for studying the structure of proteins and other macromolecules for many years. As the importance of proteins continues to grow in a wide range of research fields from basic biochemistry and biophysics to pharmaceutical development and biotechnology, more and more researchers have found a knowledge of X-ray diffraction to be an indispensable tool. Professor Drenth, recognized internationally for his numerous contributions to crystallographic research...

This serial presents current advances and reviews in cell biology - both animal and plant. Articles address structure and control of gene expression, nucleocytoplasmic interaction, control of cell development and differentiation, cell transformation, and growth. Coverage has been expanded to include molecular biology applied to cell biological systems, cell-cell interactions, cell surface and receptor phenomena, and other areas. Special topical volumes in areas of particualr growth and interest...

PCR is the most powerful technique currently used in molecular biology. It enables the scientist to quickly replicate DNA and RNA on the benchtop. From its discovery in the early 80's, PCR has blossomed into a method that enables everything from ready mutation of DNA/RNA to speedy analysis of tens of thousands of nucleotide sequences daily. PCR Applications examines the latest developments in this field. It is the third book in the series, building on the previous publications PCR Protocols and...

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen fur die historische wie auch die disziplingeschichtliche Forschung zur Verfugung, die jeweils im historischen Kontext betrachtet werden mussen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.