In quest'opera sono riportate le conoscenze piu aggiornate sulle indagini del DNA che sono comunemente utilizzate per l'identificazione di autori di reati violenti nelle indagini criminali, per l'attribuzione dell'identita a resti umani ed a vittime di disastri di massa, per la ricostruzione di rapporti parentali nelle indagini di paternita. La monografia descrive la biologia dei diversi tipi di DNA che sono utilizzati a questo scopo - i microsatelliti del DNA autosomico, il DNA mitocondriale, i...
Gene Quantification (Advanced Biomedical Technologies)
Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate...
Computational Methods in Genome Research
Chapters originating as plenary lectures at the July 1992 symposium provide a bridge between experimental databases (information) on the one hand and theoretical concepts (biological and genetic knowledge) on the other. Among the topics: informatics and experiments for the Human Genome Project; the
Microarray Analysis of the Physical Genome (Methods in Molecular Biology, #556)
In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome. In Microarray Analysis of the Physical Genome: Methods and Protocols, experts in the field cover DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity (LOH), cytosine met...
Reviews in Plant Cytogenetics
Chromosomes represent the main focus of cytogenetics. One of the main challenges of modern-day cytogenetics is to unravel the relation between the genomic content and architecture of chromosomes and their genetic function. Plant species have provided an important contribution to the knowledge of chromosome evolution, and those with large chromosomes have often been used in the study of chromosome behavior. The rapid development of molecular tools in the last few years has greatly furthered advan...
Expression Genetics (Biotechniques Update)
by Michael McClelland, Arthur B Pardee, and Michael McCelland
Genetics, Diversity, and the Biosphere
by D McLain and Denson K McLain
Mobile Genetic Elements (Methods in Molecular Biology, #260)
by Wolfgang J. Miller and Pierre Capy
Leading experts describe in step-by-step detail their most productive transposon-based methods and strategies for studying genome structure, function, and evolution. These readily reproducible techniques cover a wide range, including mutagenesis, transgenesis, gene silencing, and molecular systematics. Among the highlights are a series of DNA hybridization methods for analyzing the distribution and dynamics of mobile DNA at the hosts' genomic level, techniques for studying LTR retrotransposons i...
"Molecular Genetics of Bacteria" fulfills the need for a comprehensive, primary textbook in bacterial genetics. It is ideally suited as a textbook for advanced undergraduate level courses and as background reading for graduate level courses. It is also recommended reading for scientists in all fields of biology, many of which depend upon the concepts and techniques covered in this book. While the book concentrates on the necessity of the bacterium Escherichia coli, about which most is known, it...
Statistics in Genetics (The IMA Volumes in Mathematics and its Applications, #112)
Though the Genome Project will eventually result in the sequencing of the human genome, as well as the genomes of several other organisms, there will still be a need for good statistics for family studies of complex diseases. The papers in this volume are contributions by some of the leading researchers in the field to the current topics in statistical genetics. One section deals with DNA sequence matching and issues related to forensics, while another deals with statistical problems of modeling...
Loeffler/Petrides Biochemie Und Pathobiochemie (Springer-Lehrbuch, #1)
Jetzt kommt Bewegung in die Biochemie! Die ganze Welt der Biochemie und Pathobiochemie in 74 uberschaubaren Kapiteln und uber 1000 Abbildungen erklart - da bleibt keine Frage offen. Und mehr noch, damit Sie die komplexen Vorgange in Stoffwechsel, Signaltransduktion und Molekularbiologie schneller verstehen, sind mit der kostenlosen MoreMediaApp uber 400, teils vertonte Videos direkt aus dem Buch abrufbar - einfach das Bild mit dem Smartphone oder Tablet scannen und schon werden Citratzyklus, D...
Gehoeren Sie auch zu den Menschen, die einen Donut nur betrachten mussen, um 3 Kilo mehr auf der Waage zu haben - wohingegen andere den ganzen Tag essen koennen, ohne ein Gramm zuzunehmen? Haben Sie sich auch schon einmal gefragt, was schuld daran ist, dass Sie keinen Alkohol vertragen, beim lustigen Karaoke Abend ausgebuht werden, mit 30 schon eine Glatze haben oder so ein Morgenmuffel sind? Eine einfache Antwort auf diese Fragen ware: Das habe ich von meinen Eltern geerbt - das liegt alles nu...
Plant Molecular Evolution
Plant molecular biology has produced an ever-increasing flood of data about genes and genomes. Evolutionary biology and systematics provides the context for synthesizing this information. This book brings together contributions from evolutionary biologists, systematists, developmental geneticists, biochemists, and others working on diverse aspects of plant biology whose work touches to varying degrees on plant molecular evolution. The book is organized in three parts, the first of which i...
Methods of Microarray Data Analysis V (Lecture Notes in Physics, #339)
This book is dedicated solely to the analysis of microarray data. Its unique approach of presenting different methods by analyzing the same data set shows the strengths and weakness of each method. Part of the book is devoted to review papers, which provide a more general look at various analytical approaches. It also presents some background readings for the advanced topics discussed in the CAMDA papers.
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos--as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese...
Molekulare Populationsgenetik
by Wolfgang Stephan and Anja C Horger
Das Buch behandelt die genetische Vielfalt von Populationen von Organismen. Es erlautert, wie genetische Vielfalt gemessen wird und wie aus diesen Daten die Mechanismen untersucht werden koennen, die die Variabilitat auf der Genomebene und damit die Mikroevolution einer Population beeinflussen. Ziel dieses Buches ist es, das Wirken der naturlichen Selektion im Genom zu verstehen und vom Einfluss neutraler Evolutionskrafte (wie genetischer Drift, Mutation und Rekombination) unterscheiden zu lerne...
Introduction to Crystallography (Royal Microscopical Society Microscopy Handbooks, #19)
by Christopher Hammond
This handbook leads the reader through the basic concepts of crystallography, which are essential to an understanding of such electrical and mechanical properties as piezoelectricity and doferomation mechanisms. It begins with a description of simple crystal structures and an explanation of how more complex structures can be considered in terms of these basic units. Simple two-dimensional patterns are used to introduce the concepts of the lattice and the motif, and ideas of symmetry. These ideas...
`A manual for the new, healthy way of being dirty ... Read it, and you will learn to love your microbiota' Newsweek Obesity, autism, mental health problems, IBS, allergies, auto-immunity, cancer. Does the answer to the modern epidemic of `Western' diseases lie in our gut? You are 10% human. For every one of your cells, there are nine impostors hitching a ride. You are not just flesh and bone, but also bacteria and fungi. And you are more `them' than you are `you'. Y...
Manipulation and Expression of Recombinant DNA
by Dominique Robertson, etc., Scott Shore, and David M. Miller
This laboratory manual is designed for use in introductory biotechnology courses. Experiments are constructed in a modular fashion, lending this book both to the traditional semester course and the shorter intensive course. Its main objective is to expose students to the basic research protocols used in molecular biology and biochemistry labs. This text covers techniques in detail and teaches students to culture and transform bacteria, grow vector plasmids, purify insert DNA, ligate vector and i...