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Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsibl...

First published in 1988: This comprehensive set is crucial to the basic understanding of the immune system and is an essential component of the design and implementation of improved immunization strategies. Contains authoritative reviews of cell migration research and addresses the is-sues of lymphocyte recirculation leading to inductive interactions, and the subsequent migration and homing of effector cells generated from these responses. Systemic migration of cells from the central and periphe...

THE NEW YORK TIMES BESTSELLER'A propulsive, soulful story of mourning and gratitude - and an intimate portrait of one woman's sojourn in the wilderness between life and death.' TARA WESTOVER, author of Educated__________We all face moments that bring us to our knees: heartbreak, trauma, illness. When things don't go to plan this is the book to reach for - an inspirational memoir about what we can learn about life from a brush with death.At just twenty-two, on the cusp of adult life, Suleika Jaou...

For Blood and Money tells the little-known story of how an upstart biotechnology company created a one-in-a-million cancer drug, and how the core medical team—denied their share of the profits—went and did it again. In this epic saga of money and science, veteran financial journalist Nathan Vardi explains how the invention of two of the biggest cancer drugs in history became (for their backers) two of the greatest Wall Street bets of all time. His narrative immerses readers in the recent explosi...

Something everyone has the power to do is reduce your cancer risk, and this book will show you just how easy it is to do it. Each year, over a million people in the United States alone hear the words no one ever wants to hear: You have cancer. But what if there was a way for fewer people to hear these words? One of the biggest myths regarding cancer is that it’s mostly genetic - meaning that you have no control over whether you get it. While genetics do have an impact, the truth is that your l...

At age eleven, Katie Russell attended her first Chicago Cubs game. While dining at Harry Caray's Italian Steakhouse in the Windy City, her mother planted the seed of a big dream: to visit all of the Major League Baseball (MLB) parks. Fast-forward years later, and Katie stands on the mound at Wrigley Field, baseball and glove in hand, name displayed on the billboard for all to see. But her journey to that moment was anything but pitch perfect. Join Katie as she travels over 30,000 miles to all...

This work discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable. It focuses on what is widely viewed as the 'poster child' of rational drug development in the cancer research world. The history of the founding of a genetic mutant chromosome in the indication of Chronic myeloid leukemia disease, and the subsequent developmen...

A leading cancer specialist tells the powerful stories of 3 adult leukemia patients—shining new light on the hidden history of the disease and the drugs developed to treat it. “A look at leukemia patients’ fear, survival and grace while fighting the disease . . . a quiet chronicle of life with and beyond leukemia, and sometimes life’s end.” —The Washington Post When you are told that you have leukemia, your world stops. Your brain can’t function. You are asked to make decisions about treatm...

Poems centered on survival and perseverance in the face of long-term illness. Delivered a diagnosis of acute myeloid leukemia with a ten percent prognosis for survival, Dr. Dianne Silvestri surrenders her white coat for a hospital gown. Aided by her attentive medical team, family, and friends, she navigates the surreal world of chemotherapy, stem cell transplantation, and subsequent threats from graft-versus-host disease and serious infections of her compromised immune system. But I Still Hav...