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Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to...

This book contains the proceedings of a conference devoted to the study of the structure and function of Terminal deoxynucleotidyl Transferase (TdT) and its utilization as biochemical marker in immuno­ biology and leukemia, held in Elba, Italy on May 28-31, 1981. The en­ zyme has been known to nucleic acid biochemists for more than 20 years and has proved to be an excellent tool for making deoxypolymers, label­ ing DNA fragments, and adding homopolymer tails to restriction endonu­ clease fragmen...

Jane Tomlinson, a mother of three from Leeds, was first diagnosed with breast cancer when she was 26. Despite being given the all clear, in 2000 she learned that the disease had spread to her lungs and bones and there was nothing more the doctors could do. Faced with such devastating news, Jane did not give up. She decided to fight - the life sentence, the disease, and the expectations of living with cancer. Battling fierce pain to complete three London marathons, the Great North Run, and a 2,50...

The Monte Carlo (MC) method, established as the gold standard to predict results of physical processes, is now fast becoming a routine clinical tool for applications that range from quality control to treatment verification. This book provides a basic understanding of the fundamental principles and limitations of the MC method in the interpretation and validation of results for various scenarios. It shows how user-friendly and speed optimized MC codes can achieve online image processing or dose...

First published in 1992: This book provides a comprehensive look at the design and production of microcapsules, microspheres, and nanoparticles. It discusses the diverse aspects and skills that must be mastered to prepare and test products that will work correctly and be clinically acceptable for human or animal use.

Waiting for Cancer to Come tells the stories of women who are struggling with their high risk for cancer. Based on interviews and surveys of dozens of women, this book pieces together the diverse yet interlocking experiences of women who have tested positive for the BRCA 1/2 gene mutations, which indicate a higher risk of developing breast and ovarian cancer. Sharlene Hesse-Biber brings these narratives to light and follows women’s journeys from deciding to get screened for BRCA, to learning the...

By taking a fresh look at some of medicine's most sacrosanct dictates, Dr. Nagourney has found a better, faster, smarter way to treat even the most complex cancers.

This overview covers health-related effects of a special group of silicates, named phyllosilicates for their structure (non-fibrous platty crystals), and known for their industrial uses (filling, insulating and absorbing materials). Their most important contaminant, asbestos, is also discussed. The different chapters describe the present knowledge concerning geology, mineralogy and health-related effects (epidemiology, pathology, animal experiments, cell toxicology, carcinogenesis) of phyllosili...

A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting forst with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium-binding proteins (characterized by the EF-hand structural element), and by the calcium and phosphoslipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protei...