Single-Arm Phase II Survival Trial Design provides a comprehensive summary to the most commonly- used methods for single-arm phase II trial design with time-to-event endpoints. Single-arm phase II trials are a key component for successfully developing advanced cancer drugs and treatments, particular for target therapy and immunotherapy in which time-to-event endpoints are often the primary endpoints. Most test statistics for single-arm phase II trial design with time-to-event endpoints are not available in commercial software.
Key Features:
- Covers the most frequently used methods for single-arm phase II trial design with time-to-event endpoints in a comprehensive fashion.
- Provides new material on phase II immunotherapy trial design and phase II trial design with TTP ratio endpoint.
- Illustrates trial designs by real clinical trial examples
- Includes R code for all methods proposed in the book, enabling straightforward sample size calculation.
- ISBN13 9781000422481
- Publish Date 6 August 2021
- Publish Status Forthcoming
- Publish Country GB
- Publisher Taylor & Francis Ltd
- Imprint Chapman & Hall/CRC
- Format eBook
- Pages 263
- Language English