Nearly every cellular activity, such as cell growth, proliferation, protein synthesis and nuclear division, is regulated by protein phosphorylation/dephosphorylation on tyrosine residues as initiation events. Synchronization occurs through the interaction of protein tyrosine kinases and phosphatases. This book unveils signal pathways that connect extracellular signals with changes in the phosphorylation state of target proteins, allowing the co-ordinated and integrated modulation of mitogenic signalling. Specifically, cascades involving protein serine/threonine kinases and connections to phosphoinositide-derived second messengers are discussed.
- ISBN10 3540567453
- ISBN13 9783540567455
- Publish Date 29 July 1993
- Publish Status Active
- Out of Print 12 November 2010
- Publish Country DE
- Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
- Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K
- Format Hardcover
- Pages 387
- Language English