This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.
- ISBN10 1138557811
- ISBN13 9781138557819
- Publish Date 29 January 2019 (first published 14 July 2017)
- Publish Status Permanently Withdrawn
- Out of Print 3 February 2022
- Publish Country GB
- Publisher Taylor & Francis Ltd
- Imprint CRC Press
- Format Paperback
- Pages 176
- Language English