Blake Rayne was born in Lewes, Delaware, in 1969, and lives and works in New York. He studied at the California Institute of the Arts, and was the Director of Graduate Studies at Columbia University's School of Visual Arts from 2003 to 2009. His work has been exhibited internationally, including at the Whitney Museum of American Art, Artists Space, SculptureCenter, The Kitchen, New York; Centre Pompidou, Paris; Museum Ludwig, Cologne; Künstlerhaus, Graz; Bergen Kunsthall; and the Blaffer Art Museum, Houston. Rayne's paintings are held in the collections of the Museum of Modern Art, the Whitney Museum of American Art, FRAC Poitou-Charentes, and the Portland Museum of Art.

Artist, critic, and gallerist John Kelsey cofounded the artists' collective The Bernadette Corporation, author of the novel Reena Spaulings (Semiotext(e)).