Isabella graced the covers of Vogue, Harper's Bazaar, and Vanity Fair, becoming one of the most iconic models of the 1980s. Her acting career includes such films as David Lynch's Blue Velvet and Wild at Heart, Campbell Scott and Stanley Tucci's Big Night, Peter Weir's Fearless, and The Saddest Music in the World directed by Guy Maddin. Isabella wrote the script to My Dad is 100 Years Old, also directed by Guy Maddin, an homage to her father, the filmmaker Roberto Rossellini, and her mother, Ingrid Bergman. Green Porno is Isabella's directorial debut. She lives in New York City.