Dennis O'Brien is a Mechanical Engineer who was a senior director in an Australian consulting practice with branch offices in various locations around the world. He worked in many of these locations on major projects. While this was happening, he suffered from a rare disease caused by a tumour on the pituitary gland. Like many rare diseases this remained undiagnosed for years and had a major impact on his health. This included extensive time in hospital, a period of major psychosis and the amputation of his leg. The challenges of his profession were a key part in maintaining his enthusiasm despite his illness.