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The ability to detect and quantify apoptosis, to understand its biochemistry, and to identify its regulatory genes and proteins is crucial to biomedical research. In Apoptosis: Methods and Protocols, Second Edition, expert researchers describe the techniques to best investigate the critical steps involved in the apoptotic process. Presented from several different research perspectives, the volume contains sections covering detection of apoptosis, detection of non-apoptotic cell death, modificati...

How and why certain proteins misfold and how this misfolding is linked to many disease processes has become a well-documented topic of study. Protein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols moves beyond the basics to emphasize the molecular effects of protein misfolding at a cellular level, to delineate the impacts and cellular reactions that play a role in pathogenetic mechanisms, and to pinpoint possible manipulations and treatment strategies that can count...

This guide for the newcomer covers all areas which are basic to the performance of animal, including human, cell culture. Experienced researchers should also find it useful as a source of reference when entering a new field, or when setting up a new laboratory.

was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on...

Recent research into ploidy changes, gene and genome duplications encompasses and wide spectrum of fascinating topics. Like most fields of modern biology, polyploidy research experiences an ongoing transformation thanks to next and beyond-next generation sequencing technologies. More than 30 years ago, Lewis edited his comprehensive work on polyploid plants and animals. Although there have been efforts to bring together polyploidy researchers from botany and zoology in recent conferences, coll...

Biologists have long been puzzled by the peculiar arrangement of genes on the strands of DNA found in the cell. In particular, many genes are interrupted by non-coding regions - intervening sequences of introns - that nonetheless function in some developmental systems and probably were involved in the evolution of the earliest genes. Furthermore, biologists did not anticipate the ubiquitous existence of introns on either functional or evolutionary grounds. Thus, many questions about the evolutio...

Molecular Embryology explains in simple terms the molecular interactions that transform an egg to a complex embryo that in the end gives rise to a fully-formed animal. In doing so, the book covers one hundred and fifty years of experiments that have led to our present understanding of these molecular interactions. As the text progresses, the reader will gain a sense of the developmental similarities and differences between organisms. Students studying developmental biology and embryology will fi...

This three-volume compendium is the most comprehensive work, to date, on endothelium cells and their important role in the functions of the internal framework. The endothelial cell is broken down into its different properties, taking into consideration its part in metabolic, hemostatic, and immunological processes, as well as their interac-tion with each other and different cell types. Numerous illustrations featured throughout help clarify the importance of endothelium in maintaining the intern...

The first edition of James Putney’s Calcium Signaling offered readers a comprehensive view of the fascinating diversity of technologies that the new field of calcium signaling employed. And while that work is still regarded as a premier text on the basics of calcium signaling, progress has been so dramatic that an update is now required. In Calcium Signaling, Second Edition, Putney focuses on those processes that generate calcium signals to compile the first comprehensive exploration of calcium...

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of ap...

Water and Biological Macromolecules is a new volume in the series, Topics in Molecular and Structural Biology. Water is so ubiquitous that it has, to a greater degree, been overlooked in molecular biology. This book looks at the biochemical and thermodynamic properties in relation to polypeptides, nucleic acids, polysaccharides and lipids. Water is so pervasive that it would be an impossible task to cover all its features. With this in mind each contributor has taken special care to refer to oth...

First Published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Advanced Molecular Biology emphasises the unifying principles and mechanisms of molecular biology, with frequent use of tables and boxes to summarise experimental data and gene and protein functions. Extensive cross-referencing between chapters is used to reinforce and broaden the understanding of core concepts. This is the ideal source of comprehensive, authoritative and up-to-date information for all those whose work is in the field of molecular biology. This book emphasises the unifying princ...

This laboratory manual is designed for use in introductory biotechnology courses. Experiments are constructed in a modular fashion, lending this book both to the traditional semester course and the shorter intensive course. Its main objective is to expose students to the basic research protocols used in molecular biology and biochemistry labs. This text covers techniques in detail and teaches students to culture and transform bacteria, grow vector plasmids, purify insert DNA, ligate vector and i...

Guide to Techniques in Glycobiology, designed to serve the needs of the student, experienced researcher, and newcomer to the field, presents in one source and format a wide variety of methods, each of wchich provides background material explaining the basis of the method followed by detailed procedures. Features: * Detailed procedures newly written for this volume * Extensive practical information * Rationale and strategies for carbohydrate chain analysis