The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
- ISBN10 0801842573
- ISBN13 9780801842573
- Publish Date 1 September 1991
- Publish Status Out of Stock
- Out of Print 12 March 1999
- Publish Country US
- Imprint Johns Hopkins University Press
- Edition 2nd Revised edition
- Format Hardcover
- Pages 320
- Language English